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Titolo:
EARLY DOPPLER-ECHOCARDIOGRAPHIC - DYSFUNCTION IS ASSOCIATED WITH AN INCREASED MORTALITY AFTER ORTHOTOPIC CARDIAC TRANSPLANTATION
Autore:
ROSS HJ; GULLESTAD L; HUNT SA; TOVEY DA; PURYEAR JB; MCMILLAN A; STINSON EB; VALANTINE HA;
Indirizzi:
STANFORD UNIV,SCH MED,CVRC,DIV CARDIOVASC MED,300 PASTEUR DR,OFF 291 STANFORD CA 94305 STANFORD UNIV,SCH MED,CVRC,DIV CARDIOVASC MED STANFORD CA 94305 STANFORD UNIV,SCH MED,DEPT CARDIOVASC SURG STANFORD CA 94305 UNIV CALIF SAN FRANCISCO,CTR CANC SAN FRANCISCO CA 94143
Titolo Testata:
Circulation
fascicolo: 9, volume: 94, anno: 1996, supplemento:, S
pagine: 289 - 293
SICI:
0009-7322(1996)94:9<289:ED-DIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOGRAFT-REJECTION; DIASTOLIC FUNCTION; INDEXES; DIAGNOSIS; MARKERS; BIOPSY;
Keywords:
TRANSPLANTATION; ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Ross et al., "EARLY DOPPLER-ECHOCARDIOGRAPHIC - DYSFUNCTION IS ASSOCIATED WITH AN INCREASED MORTALITY AFTER ORTHOTOPIC CARDIAC TRANSPLANTATION", Circulation, 94(9), 1996, pp. 289-293

Abstract

Background Doppler echocardiographic (DE) diastolic dysfunction has been correlated with rejection after orthotopic cardiac transplantation(Tx). However, the relationship of early diastolic dysfunction to late outcome is unknown. The purpose of this study was to assess the correlation between early DE diastolic dysfunction and outcome after heartTx. Methods and Results Of 133 patients undergoing heart Tx between October 1990 and April 1994, 83 were identified with greater than or equal to 4 routine DE performed during the first 6 months. Assessment ofdiastolic function included measurement of isovolumic relaxation time(IVRT), pressure half-time (PHT), and peak early mitral inflow velocity (M1). Diastolic dysfunction was defined as a decrease of 15% from baseline (IVRT and PHT) or an increase of 20% (M1). A mean dysfunction score (MDS) was calculated for each patient (number of episodes of dysfunction by Doppler total number of echocardiograms performed). The population diastole MDS was determined and two groups established (group1, MDS<mean; group 2, MDS>mean). Actuarial survival, rejection, and transplant coronary artery disease (TxCAD) were compared between groups. Actuarial survival was significantly reduced in patients with greater early diastolic dysfunction (P<.05). There were 17 deaths overall: 5in group 1 (mean, 786 days) and 12 in group 2 (mean, 384 days). Therewere no significant differences in treated rejection episodes, actuarial freedom from rejection or TxCAD, immunosuppression, sex, donor age, donor ischemic time, or cytomegalovirus between the two groups. Conclusions Diastolic dysfunction within 6 months of transplant was associated with an increased late mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:50:17