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Titolo:
ACCELERATION OF THE ALCOHOL OXIDATION RATE IN RATS WITH ALOIN, A QUINONE DERIVATIVE OF ALOE
Autore:
CHUNG JH; CHEONG JC; LEE JY; ROH HK; CHA YN;
Indirizzi:
INHA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,253 YONGHYUNDONG INCHON 402751 SOUTH KOREA INHA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL INCHON 402751 SOUTH KOREA SEOUL NATL UNIV,COLL PHARM SEOUL SOUTH KOREA
Titolo Testata:
Biochemical pharmacology
fascicolo: 9, volume: 52, anno: 1996,
pagine: 1461 - 1468
SICI:
0006-2952(1996)52:9<1461:AOTAOR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL BACTERIA; DT-DIAPHORASE; METABOLISM; ETHANOL; VERA; REDUCTASE; LIVER; BARBALOIN; SYSTEM; PLANTS;
Keywords:
ALOE; ALOIN; ETHANOL METABOLISM; ALOE-EMODIN; QUINONE; QUINONE REDUCTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Chung et al., "ACCELERATION OF THE ALCOHOL OXIDATION RATE IN RATS WITH ALOIN, A QUINONE DERIVATIVE OF ALOE", Biochemical pharmacology, 52(9), 1996, pp. 1461-1468

Abstract

Aloe contains abundant aloin, a C-glycoside derivative of anthraquinone. Based on recent reports indicating that the water extract of Aloe enhances the ethanol oxidation rate and also that quinones, in general, have a functional role in elevating the alcohol oxidation rate in vivo, we have attempted to identify the quinone derivative contained in Aloe that could increase the alcohol oxidation rate. Upon oral administration of aloin (300 mg/kg) given 12 hr prior to the administration of alcohol (3.0 g/kg), the blood alcohol area under tile curve (AUG) was found to be decreased significantly (by 40%). This was supported by increases in the rates of blood alcohol elimination and the disappearance of alcohol from the body by 45 and 50%, respectively. Analysis of hepatic triglyceride (TG) levels revealed that both the ethanol and the aloin treatment alone significantly increased the TG levels in a comparable manner; however, the level obtained by the combined treatment of aloin and ethanol was not statistically different from that produced by either treatment alone. The levels of serum L-aspartate:2-oxoglutarate aminotransferase (AST) and L-alanine:2-oxoglutarate aminotransferase (ALT) activities were not increased by acute alcohol intoxication, aloin alone, or by the combined treatment of alcohol and aloin. Pretreatments with aloe-emodin, the anthraquinone aglycone of aloin, resulted in a significantly decreased blood alcohol AUC and an increase in the rate of ethanol disappearance. These results suggested that when the aloin localized primarily in the skin of Aloe is ingested, aloe emodin (the quinone aglycone) may be released, and the released quinone may produce acceleration oi the ethanol metabolism rate in vivo. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:04:00