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Titolo:
TOP-DOWN METABOLIC CONTROL ANALYSIS
Autore:
BRAND MD;
Indirizzi:
UNIV CAMBRIDGE,DEPT BIOCHEM,TENNIS COURT RD CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
Journal of theoretical biology
fascicolo: 3, volume: 182, anno: 1996,
pagine: 351 - 360
SICI:
0022-5193(1996)182:3<351:TMCA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTATO-TUBER MITOCHONDRIA; RAT-LIVER MITOCHONDRIA; DOWN ELASTICITY ANALYSIS; ENZYME-ENZYME INTERACTIONS; FLUX CONTROL COEFFICIENTS; ELECTRON-TRANSPORT CHAIN; MOIETY-CONSERVED CYCLES; STEADY-STATE TREATMENT; OXIDATIVE-PHOSPHORYLATION; PROTON LEAK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Brand, "TOP-DOWN METABOLIC CONTROL ANALYSIS", Journal of theoretical biology, 182(3), 1996, pp. 351-360

Abstract

In the top down approach to metabolic control analysis, reactions aregrouped together into a few large blocks connected by a small number of intermediates. Control is analysed by adding inhibitors or activators that work within single blocks and measuring intermediates and fluxes, or by adding new branches and measuring changes in flux. The approach is experimentally and conceptually simple, and provides a completebut coarse description of control in complex metabolic systems that are not easily accessible using other approaches. This paper gives an overview of the method, its equations and their derivations. It discusses the ways the approach has been used in organelles and cells to identify the sites of action of effecters, to measure the distribution of control by blocks of reactions, and to measure regulation by effecters. (C) 1996 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:28:16