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Titolo:
SYNONYMOUS SUBSTITUTIONS IN THE XDH GENE OF DROSOPHILA - HETEROGENEOUS DISTRIBUTION ALONG THE CODING REGION
Autore:
COMERON JM; AGUADE M;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT GENET,DIAGONAL 645 E-08071 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT GENET E-08071 BARCELONA SPAIN
Titolo Testata:
Genetics
fascicolo: 3, volume: 144, anno: 1996,
pagine: 1053 - 1062
SICI:
0016-6731(1996)144:3<1053:SSITXG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-SEQUENCE EVOLUTION; CODON USAGE BIAS; ROSY LOCUS; NUCLEOTIDE SUBSTITUTION; XANTHINE DEHYDROGENASE; ENTEROBACTERIAL GENES; MOLECULAR CLOCK; NATURAL-SELECTION; BASE COMPOSITION; NUCLEAR GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Comeron e M. Aguade, "SYNONYMOUS SUBSTITUTIONS IN THE XDH GENE OF DROSOPHILA - HETEROGENEOUS DISTRIBUTION ALONG THE CODING REGION", Genetics, 144(3), 1996, pp. 1053-1062

Abstract

The Xdh (rosy) region of Drosophila subobscura has been sequenced andcompared to the homologous region of D. pseudoobscura and D, melanogaster. Estimates of the numbers of synonymous substitutions per site (Ks) confirm that Xdh has a high synonymous substitution rate. The distributions of both nonsynonymous and synonymous substitutions along the coding region were found to be heterogeneous. Also, no relationship has been detected between Its estimates and codon usage bias along the gene, in contrast with the generally observed relationship among genes. This heterogeneous distribution of synonymous substitutions along theXdh gene, Which is expression-level independent, could be explained by a differential selection pressure on synonymous sites along the coding region acting on mRNA secondary structure. The synonymous rate in the Xdh coding region is lower in the D, subobscura than in the D. pseudoobscura lineage, whereas the reverse is true for tile Adh gene.

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Documento generato il 04/12/20 alle ore 13:08:23