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Titolo:
INTRATHECAL HUMORAL IMMUNE-RESPONSE IN HAM TSP IN RELATION TO HLA HAPLOTYPE ANALYSIS/
Autore:
KITZE B; USUKU K; YASHIKI S; IJICHI S; FUJIYOSHI T; NAKAMURA M; IZUMO S; OSAME M; SONODA S;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROL,FAC MED,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1 FUKUOKA 812 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 3 KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,CTR CHRON VIRAL DIS KAGOSHIMA 890 JAPAN
Titolo Testata:
Acta neurologica Scandinavica
fascicolo: 4, volume: 94, anno: 1996,
pagine: 287 - 293
SICI:
0001-6314(1996)94:4<287:IHIIHT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-ASSOCIATED MYELOPATHY; VIRUS TYPE-I; T-CELL LEUKEMIA; HTLV-I; CEREBROSPINAL-FLUID; SYNTHETIC PEPTIDES; ENVELOPE GLYCOPROTEINS; HAM TSP; ANTIBODIES; REGIONS;
Keywords:
HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1 (HTLV-1); HTLV-1 ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS (HAM/TSP); HUMAN LEUKOCYTE ANTIGENS (HLA); INTRATHECAL IMMUNE RESPONSE; B-CELL EPITOPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
B. Kitze et al., "INTRATHECAL HUMORAL IMMUNE-RESPONSE IN HAM TSP IN RELATION TO HLA HAPLOTYPE ANALYSIS/", Acta neurologica Scandinavica, 94(4), 1996, pp. 287-293

Abstract

Introduction - In HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), we correlated human leukocyte antigen (HLA) haplotypes to the fine specificities of intrathecally synthesized IgG antibodies against HTLV-1. Patients and methods - HLA haplotypes of HAM/TSP patients were determined by the standard NIH microcytotoxicity test and family HLA studies. IgG antibodies against HTLV-1 synthetic peptides in paired CSF and serum were measured by enzyme immunoassay, and intrathecal synthesis of antibodies was evaluated. Results - HAM/TSP patients with particular HLA haplotypes (A24Cw7B7DR1DQ5, A2Cw7B7DR1DQ5, A24Cw-B52DR15DQ6, A11Cw1B54DR4DQ4, and A24Cw1B54DR4DQ4) showed more frequently intrathecal synthesis of antibodies against HTLV-1 synthetic peptides, especially against HTLV-1 env gp21 synthetic peptides. Conclusion- In HAM/TSP, a retrovirus-induced human chronic inflammatory diseaseof the CNS, this is the first report to provide evidence that the intrathecal antiviral immune response is influenced by immunogenetic factors of the HLA complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:08:42