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Titolo:
ADJUNCTIVE NADOLOL IN THE TREATMENT OF ACUTELY AGGRESSIVE SCHIZOPHRENIC-PATIENTS
Autore:
ALLAN ER; ALPERT M; SISON CE; CITROME L; LAURY G; BERMAN I;
Indirizzi:
FRANKLIN DELANO ROOSEVELT VET AFFAIRS HOSP,PSYCHIAT SERV,BOX 100 MONTROSE NY 10548 MT SINAI SCH MED NEW YORK NY 00000 NYU,MED CTR NEW YORK NY 10016 NATHAN S KLINE INST PSYCHIAT RES ORANGEBURG NY 10962 HARVARD UNIV,TAUNTON STATE HOSP,SCH MED BOSTON MA 02115
Titolo Testata:
The Journal of clinical psychiatry
fascicolo: 10, volume: 57, anno: 1996,
pagine: 455 - 459
SICI:
0160-6689(1996)57:10<455:ANITTO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENOCEPTOR ANTAGONISTS; NEUROLEPTIC-INDUCED AKATHISIA; DOUBLE-BLIND; PROPRANOLOL; THIORIDAZINE; BEHAVIOR; VIOLENCE; BLOCKADE; RAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
E.R. Allan et al., "ADJUNCTIVE NADOLOL IN THE TREATMENT OF ACUTELY AGGRESSIVE SCHIZOPHRENIC-PATIENTS", The Journal of clinical psychiatry, 57(10), 1996, pp. 455-459

Abstract

Background: This study assessed the safety and efficacy of nadolol 120 mg/day compared with placebo, when administered adjunctively to neuroleptic in a group of acutely aggressive schizophrenic patients. Method: Thirty-four male patients enrolled in this double-blind, placebo-controlled trial. The subjects were evaluated with the Brief PsychiatricRating Scale (BPRS) and the Simpson-Angus Neurologic Rating Scale forextrapyramidal effects. The total BPRS score as well as three factors, thought disturbance, hostility, and activation, was analyzed. Results: Compared with those who received placebo, the patients taking nadolol showed significant improvement on total BPRS score, particularly onthe thought disturbance and activation factors, after the first treatment week (p = .05). By the end of the second treatment week, the patients taking placebo also began to show improvement, and the group differences were no longer significant. The patients treated with nadolol showed significantly more improvement on Simpson-Angus scores than those who received placebo (p = .03). However, there was no significant correlation between BPRS and Simpson-Angus changes. In the madolol group, patients with and without akathisia showed no significant difference in their BPRS scores. Conclusion: These findings suggest that adjunctive nadolol may be useful in the treatment of acutely aggressive schizophrenic patients by inducing a more rapid and consistent decrease ofoverall psychiatric symptoms and by reducing the extrapyramidal effects. Our results raise the possibiliity that the mechanism of action ofnadolol on psychiatric symptoms in schizophrenic patients may be different from the mechanism of improvement of neuroleptic-induced extrapyramidal symptoms and akathisia. Nadolol may be a helpful adjunctive treatment for schizophrenic patients in general and not just for those with a high hostility level.

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Documento generato il 22/01/20 alle ore 12:40:58