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Titolo:
RESPIRATORY NEURONS MEDIATING THE BREUER-HERING REFLEX PROLONGATION OF EXPIRATION IN RAT
Autore:
HAYASHI F; COLES SK; MCCRIMMON DR;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL M211,303 E CHICAGO AVE CHICAGOIL 60611 NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL M211 CHICAGO IL 60611 CHIBA UNIV,SCH MED,DEPT PHYSIOL 2,CHUO KU CHIBA 260 JAPAN UNIV HOSP CLEVELAND,DEPT MED,DIV PULM & CRIT CARE MED CLEVELAND OH 44106
Titolo Testata:
The Journal of neuroscience
fascicolo: 20, volume: 16, anno: 1996,
pagine: 6526 - 6536
SICI:
0270-6474(1996)16:20<6526:RNMTBR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY STRETCH RECEPTORS; INSPIRATORY NEURONS; BOTZINGER COMPLEX; FUNCTIONAL ASSOCIATIONS; VENTROLATERAL MEDULLA; INHIBITORY ACTIONS; RHYTHM GENERATION; DECEREBRATE RAT; CAT; DORSAL;
Keywords:
BREUER-HERING REFLEX; CONTROL OF BREATHING; PULMONARY STRETCH RECEPTOR; RESPIRATORY PATTERN; VAGUS NERVE; VENTRAL RESPIRATORY GROUP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
F. Hayashi et al., "RESPIRATORY NEURONS MEDIATING THE BREUER-HERING REFLEX PROLONGATION OF EXPIRATION IN RAT", The Journal of neuroscience, 16(20), 1996, pp. 6526-6536

Abstract

Afferent input from pulmonary stretch receptors is important in the control of the timing of inspiratory and expiratory phases of the respiratory cycle. The current study was undertaken to identify neurons within a column of respiratory neurons in the ventrolateral medulla (termed the ventral respiratory group, VRG) that, when activated by lung inflation, produce the Breuer-Hering (BH) reflex in which lung inflationcauses inspiratory termination and expiratory prolongation. Intracellular recordings of VRG neurons revealed three groups of inspiratory (I) and two groups of expiratory (E) neurons similar to previous descriptions: I-augmenting (I-Aug), I-decrementing (I-Dec), I-plateau (I-All), E-augmenting (E-Aug), and E-decrementing (E-Dec) neurons. Low-intensity, low-frequency stimulation of a vagus nerve elicited paucisynapticEPSPs in E-Dec, I-Aug, and I-All neurons that could be divided into two groups on the basis of latency (2.8 +/- 0.1 msec, n = 10; 4.0 +/- 0.1 msec, n = 17). IPSPs were elicited in I-Aug and I-All neurons (4.8 /- 0.1 msec, n = 12). However, only E-Dec neurons were depolarized when the BH reflex was activated by lung inflation (7.5 cm H2O) or mimicked by vagus nerve stimulation (50 Hz). All other neurons were hyperpolarized and ceased firing during BH reflex-mediated expiratory prolongation. A subset of E-Dec neurons (termed E-Dec(early)) discharged before inspiratory termination and could contribute to inspiratory termination. The findings are consistent with the hypothesis that a group of E-Dec neurons receives a paucisynaptic (probably disynaptic) input from pulmonary afferents and, in turn, inhibits inspiratory neurons, thereby lengthening expiration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:56:30