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Titolo:
LINOMIDE, AN IMMUNOMODULATOR THAT INHIBITS T(H)1 CYTOKINE GENE-EXPRESSION
Autore:
ARAD G; KATZENELLENBOGEN M; LEVY R; SLAVIN S; KAEMPFER R;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANTAT IL-91120 JERUSALEM ISRAEL
Titolo Testata:
International immunology
fascicolo: 10, volume: 8, anno: 1996,
pagine: 1603 - 1607
SICI:
0953-8178(1996)8:10<1603:LAITIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN INTERLEUKIN-2; T-CELL; INTERFERON; DEATH; QUINOLINE-3-CARBOXAMIDE; SUPERINDUCTION; STIMULATION; RAT;
Keywords:
IMMUNOSUPPRESSION; LINOMIDE; SUPERANTIGEN; T(H)1 CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Arad et al., "LINOMIDE, AN IMMUNOMODULATOR THAT INHIBITS T(H)1 CYTOKINE GENE-EXPRESSION", International immunology, 8(10), 1996, pp. 1603-1607

Abstract

Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer, In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. In contrast to these clear effects in vivo, attempts to show an effect of linomide in vitro have notbeen successful and its mode of action remains to be elucidated, Herewe show that at concentrations effective in vivo, linomide is active on human peripheral blood mononuclear cells (PBMC), severely inhibiting the induction by Staphylococcus aureus enterotoxin B of mRNA of three cytokine genes expressed in T(h)1 cells, those for IFN-gamma, IL-2, and tumor necrosis factor-beta, Vet, cell viability was not affected by linomide, The extent of inhibition is dose-dependent on linomide, Linomide also blocked induction of IL-2 and IFN-gamma mRNA by phytohemagglutinin, The inhibitory effect is expressed immediately but can be enhanced significantly by a prolonged exposure of PBMC to linomide, reaching 10-fold, These results support the concept that linomide antagonizes the activation of T(h)1 cells during a cellular immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:12:22