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Titolo:
PROSTACYCLIN INCREASES DISTAL TUBULE HCO3 SECRETION IN THE RAT
Autore:
WESSON DE;
Indirizzi:
TEXAS TECH UNIV,HLTH SCI CTR,RENAL SECT,3601 4TH ST LUBBOCK TX 79430 BAYLOR COLL MED,VET AFFAIRS MED CTR HOUSTON TX 77030
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 6, volume: 40, anno: 1996,
pagine: 1183 - 1192
SICI:
0363-6127(1996)40:6<1183:PIDTHS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BICARBONATE REABSORPTION; CHRONIC METABOLIC ALKALOSIS; CORTICAL COLLECTING DUCT; IN-VIVO; INVIVO; NEPHRON; CELLS; TRANSPORT; ACIDIFICATION; KIDNEY;
Keywords:
ACIDIFICATION; ALKALI; ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE; DIET; MICROPUNCTURE; PROSTAGLANDINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Wesson, "PROSTACYCLIN INCREASES DISTAL TUBULE HCO3 SECRETION IN THE RAT", American journal of physiology. Renal, fluid and electrolyte physiology, 40(6), 1996, pp. 1183-1192

Abstract

We examined whether prostacyclin (PGI(2)), a prostaglandin synthesized in the renal cortex that increases adenosine 3',5'-cyclic monophosphate levels in distal nephron epithelia, mediates increased HCO3 secretion in in vivo perfused distal tubules of anesthetized rats given dietary HCO3. Animals eating a minimum electrolyte diet given 80 mM NaHCO3drinking solution increased urine excretion of 6-keto-PGF(1 alpha), aPGI(2) metabolite, by 2.6 +/- 0.3-fold compared with those drinking distilled H2O. NaHCO3 animals infused with indomethacin to inhibit PGI(2) synthesis had lower HCO3 secretion than those without indomethacin (-8.9 +/- 0.9 vs. -18.7 +/- 1.8 pmol . mm(-1). min(-1), P < 0.01). By contrast, NaHCO3 animals infused with both PGI(2) and indomethacin hadhigher HCO3 secretion than those given indomethacin alone (-16.0 +/- 1.5, P < 0.02 vs. indomethacin group). HCO3 secretion was not different between controls with and without indomethacin but was higher in thePGI(2) + indomethacin compared with the indomethacin alone controls (-11.2 +/- 1.2 vs. -4.5 +/- 0.5, P < 0.01). The data show that PGI(2) increases distal tubule HCO3 secretion in rats and suggest that this agent contributes to the increased distal tubule HCO3 secretion induced by dietary HCO3.

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Documento generato il 01/10/20 alle ore 14:47:46