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Titolo:
ROLE OF EXTRACELLULAR-MATRIX PROTEINS IN REGULATION OF HUMAN GLIOMA CELL INVASION IN-VITRO
Autore:
CHINTALA SK; GOKASLAN ZL; GO Y; SAWAYA R; NICOLSON GL; RAO JS;
Indirizzi:
UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT NEUROSURG,BOX 064,1515 HOLCOMBE BLVD HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT NEUROSURG HOUSTON TX 77030 UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT TUMOR BIOL HOUSTON TX 77030
Titolo Testata:
Clinical & experimental metastasis
fascicolo: 4, volume: 14, anno: 1996,
pagine: 358 - 366
SICI:
0262-0898(1996)14:4<358:ROEPIR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NERVOUS SYSTEMS; IN-VITRO; MIGRATION; INVITRO; LAMININ; HETEROGENEITY; PROLIFERATION; GANGLIOSIDES; ASTROCYTES; CULTURE;
Keywords:
COLLAGEN; EXTRACELLULAR MATRIX; GLIOMA; INVASION; MIGRATION; SPHEROID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Chintala et al., "ROLE OF EXTRACELLULAR-MATRIX PROTEINS IN REGULATION OF HUMAN GLIOMA CELL INVASION IN-VITRO", Clinical & experimental metastasis, 14(4), 1996, pp. 358-366

Abstract

Primary brain turners lack the metastatic behavior that is in part believed to be promoted by the extracellular matrix (ECR;I) components of the basement membrane, This study was intended to examine the influence of the ECM components present in the basement membrane that may act as natural barriers to tumor cell invasion, We examined the effect of type I and type IV collagens, fibronectin, laminin, and hyaluronic acid on the migration and invasion of four established glioblastoma cell lines, SNB19, U251, UWR1, and UWR2, Lower concentrations of all the ECM components induced the migration and invasion of all the cell lines. However, in the case of SNB19, laminin inhibited both migration andinvasion in a concentration-dependent manner. We have also examined the influence of individual ECM components on the migration of cells from a spheroid to a monolayer on ECM component-coated coverslips. Consistent with the invasion studies using the modified Boyden chamber assays, lower concentrations of ECM components induced the migration of cells from spheroids to monolayer, Again, laminin inhibited the migration of cells from SNB19 spheroids. These results indicate that ECM components induce the invasion of glioma cells, apart from components like laminin, which may act as natural inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:53:53