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Titolo:
ESTROGEN-RECEPTOR IMMUNOCYTOCHEMISTRY IN ENDOMETRIAL CARCINOMA - A PROGNOSTIC MARKER FOR SURVIVAL
Autore:
PERTSCHUK LP; MASOOD S; SIMONE J; FELDMAN JG; FRUCHTER RG; AXIOTIS CA; GREENE GL;
Indirizzi:
BOX 25,450 CLARKSON AVE BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT PATHOL BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT OBSTET & GYNECOL BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT COMMUNITY HLTH & PREVENT MED BROOKLYN NY 11203 UNIV FLORIDA,HLTH SCI CTR,DEPT PATHOL JACKSONVILLE FL 32209 OSCHNER FDN HOSP,DEPT OBSTET & GYNECOL NEW ORLEANS LA 00000 UNIV CHICAGO,BEN MAY INST CHICAGO IL 60637
Titolo Testata:
Gynecologic oncology
fascicolo: 1, volume: 63, anno: 1996,
pagine: 28 - 33
SICI:
0090-8258(1996)63:1<28:EIIEC->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; PROGESTERONE-RECEPTOR; STEROID-RECEPTORS; IMMUNOHISTOCHEMICAL EVALUATION; ASSAY; CANCER; ADENOCARCINOMA; LOCALIZATION; BREAST; PROBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L.P. Pertschuk et al., "ESTROGEN-RECEPTOR IMMUNOCYTOCHEMISTRY IN ENDOMETRIAL CARCINOMA - A PROGNOSTIC MARKER FOR SURVIVAL", Gynecologic oncology, 63(1), 1996, pp. 28-33

Abstract

Only a few parameters such as tumor grade and stage are of value in prognosticating disease course in endometrial carcinoma, Biochemical steroid hormone receptor assays could also be useful but are difficult to perform and interpret. Immunocytochemical assay (ICA) might be the method of choice for detecting endometrial receptors, Methods: Frozen tissue from 78 cases of endometrial adenocarcinoma was examined for thepresence of estrogen (ER) and progesterone receptors (PgR) with specific monoclonal anti-receptor antibodies and the peroxidase-antiperoxidase method, In over 60 cases, frozen tissue was also assayed for ER and PgR by biochemical means, Results: Fifty-five (71%) of the endometrial carcinomas were ERICA-positive and 55 (71%) PgRICA-positive. Although both ERICA and PgRICA correlated significantly with biochemical ER and PgR only ERICA was predictive of survival, A woman with a negativeERICA was 4 times more likely to die of her disease than if she were ERICA-positive (P = 0.009; mean follow-up, 37.5 months), Three cases ERICA-positive and PgRICA-negative survived while 3 others ERICA-negative and PgRICA-positive died. Conclusion: ERICA, a technique easy to perform and interpret at the community hospital level, appears to provide prognostic information independent of tumor stage and grade, Such information might be of value in planning postoperative therapies for women with endometrial cancer. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:55:59