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Titolo:
LACTATE ACCUMULATION DURING MODERATE HYPOXIC HYPOXIA IN NEOCORTICAL RAT-BRAIN
Autore:
PAYEN JF; LEBARS E; WUYAM B; TROPINI B; PEPIN JL; LEVY P; DECORPS M;
Indirizzi:
CHU GRENOBLE,HOP A MICHALLON,INSERM,U438,PAVILLON B F-38000 GRENOBLE FRANCE HOP ALBERT MICHALLON,INSERM,U438 GRENOBLE FRANCE HOP ALBERT MICHALLON,DEPT ANESTHESIOL GRENOBLE FRANCE HOP ALBERT MICHALLON,LAB PRETA GRENOBLE FRANCE UNIV GRENOBLE 1 F-38041 GRENOBLE FRANCE
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 6, volume: 16, anno: 1996,
pagine: 1345 - 1352
SICI:
0271-678X(1996)16:6<1345:LADMHH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; CEREBRAL BLOOD-FLOW; METABOLISM; SPECTROSCOPY; HYPOXEMIA; ISCHEMIA; INVIVO; P-31; OXYGENATION; ISOFLURANE;
Keywords:
HYPOXIA; BRAIN; LACTATE; H-1 NMR SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Payen et al., "LACTATE ACCUMULATION DURING MODERATE HYPOXIC HYPOXIA IN NEOCORTICAL RAT-BRAIN", Journal of cerebral blood flow and metabolism, 16(6), 1996, pp. 1345-1352

Abstract

Neocortical metabolism was studied during moderate hypoxic hypoxia, reoxygenation, and postmortem periods in anesthetized normocapnic rats using H-1 nuclear magnetic resonance (NMR) spectroscopic imaging. Ratswere prepared with unilateral common carotid occlusion to determine the ipsilateral metabolic effects of inadequate cerebral blood flow (CBF) response to hypoxia. No difference in brain metabolism between the two hemispheres was found during the control period. Hypoxic hypoxia (P(a)o(2) = 54.1 +/- 5.8 mm Hg) resulted in a significant rise in neocortical lactate peak in both hemispheres, with an additional marked rise in the clamped side compared to the unclamped side (53 +/- 27 vs. 22+/- 13% of postmortem value, p < 0.001). These lactate changes were not reversible within 30 min of reoxygenation in the clamped hemisphere. No changes in neocortical lactate peak were observed while elevatingarterial lactate via intravenous lactate infusion without hypoxia. Inaddition, hypoxic hypoxia resulted in an apparent decrease in neocortical water and N-acetyl aspartate (NAA) signals, which were related toa shortening in T-2 relaxation times. It is concluded that neocortical lactate is an early metabolic indicator during moderate hypoxic hypoxia in normocapnic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:54:23