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Titolo:
REDUCED TRANSIT-TIME SENSITIVITY IN NONINVASIVE MAGNETIC-RESONANCE-IMAGING OF HUMAN CEREBRAL BLOOD-FLOW
Autore:
ALSOP DC; DETRE JA;
Indirizzi:
UNIV PENN,MED CTR,DEPT RADIOL,3400 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT NEUROL PHILADELPHIA PA 19104
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 6, volume: 16, anno: 1996,
pagine: 1236 - 1249
SICI:
0271-678X(1996)16:6<1236:RTSINM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HETEROGENEOUS SPIN SYSTEMS; BRAIN PERFUSION; ARTERIAL WATER; LONGITUDINAL MAGNETIZATION; SELECTIVE SATURATION; CROSS-RELAXATION; NMR RELAXATION; RAT-BRAIN; INVERSION;
Keywords:
MAGNETIC RESONANCE IMAGING; ARTERIAL TRANSIT TIME; PERFUSION; FUNCTIONAL IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Alsop e J.A. Detre, "REDUCED TRANSIT-TIME SENSITIVITY IN NONINVASIVE MAGNETIC-RESONANCE-IMAGING OF HUMAN CEREBRAL BLOOD-FLOW", Journal of cerebral blood flow and metabolism, 16(6), 1996, pp. 1236-1249

Abstract

Herein, we present a theoretical framework and experimental methods to more accurately account for transit effects in quantitative human perfusion imaging using endogenous magnetic resonance imaging (MRI) contrast. The theoretical transit time sensitivities of both continuous and pulsed inversion spin tagging experiments are demonstrated. We propose introducing a delay following continuous labeling, and demonstrate theoretically that introduction of a delay dramatically reduces the transit time sensitivity of perfusion imaging. The effects of magnetization transfer saturation on this modified continuous labeling experiment are also derived, and the assumption that the perfusion signal resides entirely within tissue rather than the arterial microvasculature isexamined. We present results demonstrating the implementation of the continuous tagging experiment with delay on an echoplanar scanner for measuring cerebral blood now (CBF) in normal volunteers. By varying the delay, we estimate transit times in the arterial system, values thatare necessary for assessing the accuracy of our quantification. The effect of uncertainties in the transit time from the tagging plane to the arterial microvasculature and the transit rime to the tissue itselfon the accuracy of perfusion quantification is discussed and found tobe small in gray matter but still potentially significant in white matter. A novel method far measuring T-1, which is fast, insensitive to contamination by cerebrospinal fluid, and compatible with the application of magnetization transfer saturation, is also presented. The methods are combined to produce quantitative maps of resting and hypercarbic CBF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:32:51