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Titolo:
DURATION THRESHOLD OF INDUCED HYPERTENSION ON CEREBRAL BLOOD-FLOW, ENERGY-METABOLISM, AND EDEMA AFTER TRANSIENT FOREBRAIN ISCHEMIA IN GERBILS
Autore:
HOSOMI N; TSUDA Y; ICHIHARA SI; KITADAI M; OHYAMA H; MATSUO H;
Indirizzi:
KAGAWA MED SCH,DEPT INTERNAL MED 2,1750-1 IKENOBE,MIKI CHO KAGAWA 76107 JAPAN
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 6, volume: 16, anno: 1996,
pagine: 1224 - 1229
SICI:
0271-678X(1996)16:6<1224:DTOIHO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ARTERY OCCLUSION; BRAIN-BARRIER; NEURONAL INJURY; RESTORATION; PRESSURE; RAT;
Keywords:
CEREBRAL ISCHEMIA; CEREBRAL BLOOD FLOW; BRAIN ENERGY METABOLISM; EDEMA; GERBILS; INDUCED HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
N. Hosomi et al., "DURATION THRESHOLD OF INDUCED HYPERTENSION ON CEREBRAL BLOOD-FLOW, ENERGY-METABOLISM, AND EDEMA AFTER TRANSIENT FOREBRAIN ISCHEMIA IN GERBILS", Journal of cerebral blood flow and metabolism, 16(6), 1996, pp. 1224-1229

Abstract

We have investigated whether there is a duration threshold for the effects of phenylephrine-induced hypertension on CBF, brain energy metabolism, and cerebral parenchymal specific gravity (SG) following transient forebrain ischemia in gerbils. Sixty gerbils were randomly assigned to one of the four treatment groups: one control group and three groups subjected to an increase of 25 mm Hg in MABP induced by treatment,30 min after reperfusion, with phenylephrine for 15 min, 30 min, or 60 min, The local CBF was measured continuously, and the SG was evaluated 120 min after reperfusion. Sequential changes in brain energy metabolism, as shown by the ratio of phosphocreatine to inorganic phosphate(Pi), the beta-ATP/Pi ratio, and intracellular pH, were also measured. The 15-min induced hypertension regimen was most suited to the recovery of brain energy metabolism, which was associated with an increase in local CBF and a decrease in cerebral edema. These results demonstrate that a suitable duration can be chosen to optimize the beneficial effects of phenylephrine-induced hypertension on ischemic brain injury following transient forebrain ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:52:12