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Titolo:
HEMATOPOIETIC AUGMENTATION BY A BETA-(1,4)-LINKED MANNAN
Autore:
EGGER SF; BROWN GS; KELSEY LS; YATES KM; ROSENBERG LJ; TALMADGE JE;
Indirizzi:
UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,600 S 42ND ST OMAHA NE 68198 UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL OMAHA NE 68198 CARRINGTON LABS INC IRVING TX 75062
Titolo Testata:
Cancer immunology and immunotherapy
fascicolo: 4, volume: 43, anno: 1996,
pagine: 195 - 205
SICI:
0340-7004(1996)43:4<195:HABABM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROID PROGENITOR CELLS; PLURIPOTENT STEM-CELLS; SOLUBLE GLUCAN; IRRADIATED MICE; COMPLEX CARBOHYDRATE; MURINE HEMATOPOIESIS; ACEMANNAN; MACROPHAGES; PARTICULATE; ENHANCEMENT;
Keywords:
HEMATOPOIESIS; MYELOSUPPRESSION; G-CSF; CFU-C; HPP-CFC; ACETYLATED MANNAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Egger et al., "HEMATOPOIETIC AUGMENTATION BY A BETA-(1,4)-LINKED MANNAN", Cancer immunology and immunotherapy, 43(4), 1996, pp. 195-205

Abstract

CARN 750 (injectable acemannan) is a polydispersed beta-(1,4)-linked acetylated mannan isolated from the Aloe barbadensis plant. It has multiple therapeutic properties including activity in wound repair and asa biological agent for the treatment of neoplasia in animals as well as the ability to activate macrophages. We report herein that CARN 750directly or indirectly has significant hematoaugmenting properties. We observed that the subcutaneous administration of CARN 750 significantly increases splenic and peripheral blood cellularity, as well as hematopoietic progenitors in the spleen and bone marrow as determined by the interleukin-3-responsive colony-forming unit culture assay and thehigh-proliferative-potential colony-forming-cell (HPP-CFC) assay (a measure of primitive hematopoietic precursors) in myelosuppressed (7 Gy) C(57)BL/6 mice. The greatest hematopoietic effect was observed following sublethal irradiation in mice receiving 1 mg CARN 750/animal, with less activity observed at higher or lower doses. Further, CARN 750, following daily injection, has activity equal to or greater than the injection of an optimal dose of granulocyte-colony-stimulating factor (G-CSF) in myelosuppressed mice. In this comparison, significantly greater activity was observed in the splenic and peripheral blood cellularity, and in the frequency and absolute number of splenic HPP-CFC as compared to the mice receiving G-CSF at 3 mu g/animal. CARN 750, when administered to myelosuppressed animals. decreased the frequency of lymphocytes with a concomitant significant increase in the frequency of polymorphonuclear leukocytes (PMN). However, owing to the increased cellularity, a significant increase in the absolute number of PMN, lymphocytes, monocytes and platelets was observed, suggesting activity on multiple cell lineages. The latter is the primary difference in activity as compared to G-CSF which has activity predominantly on PMN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 18:46:49