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Titolo:
ENERGY-EXPENDITURE IN OBSTRUCTIVE SLEEP-APNEA - EFFECTS OF TREATMENT WITH CONTINUOUS POSITIVE AIRWAY PRESSURE
Autore:
STENLOF K; GRUNSTEIN R; HEDNER J; SJOSTROM L;
Indirizzi:
SAHLGRENSKA SJUKUSET,DEPT MED,VITA STRAKET 15 S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT MED S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURG SWEDEN ROYAL PRINCE ALFRED HOSP,SLEEP DISORDERS CTR SYDNEY NSW 20501 AUSTRALIA
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 6, volume: 34, anno: 1996,
pagine: 1036 - 1043
SICI:
0193-1849(1996)34:6<1036:EIOS-E>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-COMPOSITION; BLOOD-PRESSURE; METABOLIC-RATE; GROWTH; ADULTS; COST;
Keywords:
OBESITY; SNORING; METABOLIC RATE; PROCOLLAGEN III PEPTIDE; CATECHOLAMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K. Stenlof et al., "ENERGY-EXPENDITURE IN OBSTRUCTIVE SLEEP-APNEA - EFFECTS OF TREATMENT WITH CONTINUOUS POSITIVE AIRWAY PRESSURE", American journal of physiology: endocrinology and metabolism, 34(6), 1996, pp. 1036-1043

Abstract

We examined 24-h energy expenditure (EE) in a chamber for indirect calorimetry in five male patients with obstructive sleep apnea (OSA) andsix snoring control subjects (snorers). The 24-h EE was remeasured inpatients with OSA after 3-mo treatment with nasal continuous positiveairway pressure (CPAP). Patients with OSA had a greater degree of severe sleep-breathing disturbance than snorers. Patients with OSA had higher 24-h EE [39.2 +/- 3.0 vs. 33.9 +/- 2.7 kcal . 24 h(-1) kg fat-free mass (FFM)(-1), P < 0.05], daytime urinary norepinephrine and vanillylmandelic acid (VMA), and aminoterminal procollagen III peptide (PIIIp) levels, and they tended to have higher sleeping EE (32.4 +/- 4.1 vs. 26.3 +/- 1.9 kcal . 24 h(-1) . kg FFM(-1), P < 0.1) than snorers. CPAP treatment normalized sleep architecture and breathing. CPAP treatment also decreased sleep EE (from 32.4 +/- 4.1 to 27.2 +/- 1.4 kcal . 24 h(-1) . kg FFM(-1), P < 0.05) and EE variability during sleep (from 1.6 +/- 0.5 to 1.0 +/- 9.5 kcal . 24 h(-1) . kg FFM(-1), P < 0.05) andincreased the basal metabolic rate-to-sleep EE ratio in all subjects. Serum PIIIp and plasma norepinephrine decreased after CPAP in all patients. We conclude that OSA is associated with an increased sleep EE, which is normalized by treatment with CPAP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:09:56