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Titolo:
INCREASED GI-ALPHA AND GO-ALPHA MESSENGER-RNAS IN HIPPOCAMPUS AFTER REPEATED METHAMPHETAMINE ADMINISTRATION
Autore:
UJIKE H; AKIYAMA K; KURODA S;
Indirizzi:
NIDA,MOL NEUROBIOL BRANCH,NIH,POB 5180 BALTIMORE MD 21224 OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT OKAYAMA 700 JAPAN
Titolo Testata:
NeuroReport
fascicolo: 12, volume: 7, anno: 1996,
pagine: 2036 - 2040
SICI:
0959-4965(1996)7:12<2036:IGAGMI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; BEHAVIORAL SENSITIZATION; INSITU HYBRIDIZATION; ADENYLYL CYCLASE; SIGMA RECEPTORS; G-PROTEINS; RAT-BRAIN; COCAINE; MORPHINE; ALTERS;
Keywords:
AMPHETAMINE/METHAMPHETAMINE; G PROTEIN; DRUG DEPENDENCE; BEHAVIORAL SENSITIZATION; IN SITU HYBRIDIZATION; HIPPOCAMPUS; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Ujike et al., "INCREASED GI-ALPHA AND GO-ALPHA MESSENGER-RNAS IN HIPPOCAMPUS AFTER REPEATED METHAMPHETAMINE ADMINISTRATION", NeuroReport, 7(12), 1996, pp. 2036-2040

Abstract

CHANGES in transcription of Gs alpha, Gi2 alpha: and Go alpha proteins after repeated methamphetamine administration were investigated using in situ hybridization. Rats received daily injections of methamphetamine (4 mg kg(-1)) for 14 days. Four hours after the last injection, Go alpha mRNA showed an increase of 16.6-31.6% in CA1, CA3 and dentate gyrus of the hippocampus. Gi alpha mRNA level increased by 24.2% in CA1, while Gs alpha mRNA remained unaffected. Go alpha and Gi alpha mRNAreturned to basal levels after 48 h abstinence. The expression of these G alpha mRNA in other brain regions, including substantia nigra, ventral tegmentum area, striatum, accumbens and cortices, was unchanged. The increase in Go alpha and Gi alpha mRNAs restricted only to the hippocampus after repeated methamphetamine administration may be involved in the development of dependence rather than behavioral sensitization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:13:32