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Titolo:
LEVOSULPIRIDE IN FUNCTIONAL DYSPEPSIA - A MULTICENTRIC DOUBLE-BLIND, CONTROLLED TRIAL
Autore:
CORAZZA GR; BIAGI F; ALBANO O; PORRO GB; CHELI R; MAZZACCA G; MIGLIO F; NACCARATO R; QUAGLINO D; SURRENTI C; VERME G; GASBARRINI G;
Indirizzi:
POLICLIN S ORSOLA,VIA MASSARENTI 9 I-40138 BOLOGNA ITALY UNIV AQUILA,CATTEDRA FISIOPATOL MED I-67100 LAQUILA ITALY UNIV BARI,IST CLIN MED 1 I-70121 BARI ITALY OSPED L SACCO,DIV GASTROENTEROL MILAN ITALY OSPED SAN MARTINO GENOVA,DIV GASTROENTEROL GENOA ITALY UNIV NAPLES,CATTEDRA GASTROENTEROL I-80138 NAPLES ITALY OSPED MALPIGHI BOLOGNA,DIV MED INTERNA BOLOGNA ITALY UNIV PADUA,CATTEDRA GASTROENTEROL I-35100 PADUA ITALY UNIV AQUILA,CATTEDRA MED INTERNA I-67100 LAQUILA ITALY UNIV FLORENCE,CATTEDRA GASTROENTEROL I-50121 FLORENCE ITALY OSPED MOLINETTE,DIV GASTROENTEROL TURIN ITALY UNIV CATTOLICA SACRO CUORE,CATTEDRA MED INTERNA ROME ITALY
Titolo Testata:
The Italian Journal of Gastroenterology
fascicolo: 6, volume: 28, anno: 1996,
pagine: 317 - 323
SICI:
0392-0623(1996)28:6<317:LIFD-A>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED EVALUATION; NON-ULCER DYSPEPSIA; DRUG-TREATMENT; DOMPERIDONE; SYMPTOMS; CISAPRIDE; METOCLOPRAMIDE; GASTROPARESIS; PREVALENCE; COMMUNITY;
Keywords:
ANTIDOPAMINERGIC DRUGS; FUNCTIONAL DYSPEPSIA; LEVOSULPIRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Corazza et al., "LEVOSULPIRIDE IN FUNCTIONAL DYSPEPSIA - A MULTICENTRIC DOUBLE-BLIND, CONTROLLED TRIAL", The Italian Journal of Gastroenterology, 28(6), 1996, pp. 317-323

Abstract

Abnormalities in gastrointestinal motility have been reported in a substantial proportion of patients with functional dyspepsia, supportingthe use of prokinetic drugs for treatment of dyspeptic symptoms, To evaluate efficacy and safety of levosulpiride in short-term treatment, 1298 patients were enrolled in a double-blind multicentric study carried out in 45 Italian Gastroenterology Departments, Patients were randomly assigned to either levosulpiride (25 mg tid), domperidone (10 mg tid), metoclopramide (10 mg tid) or placebo (1 tablet tid) for 4 weeks,Patients were selected on the basis of: a) occurrence in the last 4 weeks of at least 5/10 selected symptoms (anorexia, nausea, vomiting, upper abdominal pain, postprandial bloating, abdominal fullness, early satiety, belching, heartburn, regurgitation), severity of which shouldreach/exceed a total score of 8, as assessed by a specific scale ranging from 0 (absent) to 3 (severe); b) normal results of routine biochemical, ultrasound and endoscopic examinations, In addition, each patient subjectively evaluated efficacy of treatment by a visual analogue scale. Significant improvement was recorded for all symptoms at days 10and 28 in all groups (p<0.001), but levosulpiride was significantly (p<0.01) superior to domperidone, metoclopramide and placebo both in the overall clinical improvement scale as well as in a subgroup of symptoms (postprandial bloating, epigastric pain, heartburn), Active treatments and placebo were comparable as far as concerns occurrence of side-effects (12-20%) including galactorrhoea, breast tenderness and menstrual changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:14:04