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Titolo:
CELL STRESS-REGULATED HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENE EXPRESSED IN GASTROINTESTINAL EPITHELIUM
Autore:
GROH V; BAHRAM S; BAUER S; HERMAN A; BEAUCHAMP M; SPIES T;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,DIV CLIN RES,1124 COLUMBIA ST SEATTLE WA98104 FRED HUTCHINSON CANC RES CTR,DIV CLIN RES SEATTLE WA 98104 BASEL INST IMMUNOL CH-4005 BASEL SWITZERLAND
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 93, anno: 1996,
pagine: 12445 - 12450
SICI:
0027-8424(1996)93:22<12445:CSHMHC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMUS LEUKEMIA ANTIGEN; DELTA-T-CELLS; INTESTINAL EPITHELIUM; NONCLASSICAL MHC; LYMPHOCYTES-T; RECEPTOR; PEPTIDE; RECOGNITION; MOLECULE; HSP70;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
V. Groh et al., "CELL STRESS-REGULATED HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENE EXPRESSED IN GASTROINTESTINAL EPITHELIUM", Proceedings of the National Academy of Sciences of the United Statesof America, 93(22), 1996, pp. 12445-12450

Abstract

Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Twohighly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta(2)-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may functionas an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:34:44