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Titolo:
INFARCTLIKE LESIONS IN THE BRAIN - PREVALENCE AND ANATOMIC CHARACTERISTICS AT MR-IMAGING OF THE ELDERLY - DATA FROM THE CARDIOVASCULAR HEALTH STUDY
Autore:
BRYAN RN; WELLS SW; MILLER TJ; ELSTER AD; JUNGREIS CA; POIRIER VC; LIND BK; MANOLIO TA;
Indirizzi:
JOHNS HOPKINS MED INST,DIV NEURORADIOL,600 N WOLFE ST BALTIMORE MD 21287 WAKE FOREST UNIV,BOWMAN GRAY SCH MED WINSTON SALEM NC 00000 PRESBYTERIAN UNIV HOSP PITTSBURGH PA 15213 UNIV CALIF DAVIS SACRAMENTO CA 95817 CARDIOVASC HLTH STUDY COORDINATING CTR SEATTLE WA 00000 NHLBI,NIH BETHESDA MD 20892
Titolo Testata:
Radiology
fascicolo: 1, volume: 202, anno: 1997,
pagine: 47 - 54
SICI:
0033-8419(1997)202:1<47:ILITB->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACUNAR INFARCTION; AGING BRAIN; OLDER ADULTS; RISK-FACTORS; STROKE; POPULATION; DISEASE; TOMOGRAPHY; REGISTRY; FEATURES;
Keywords:
BRAIN, INFARCTION; BRAIN, MR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Bryan et al., "INFARCTLIKE LESIONS IN THE BRAIN - PREVALENCE AND ANATOMIC CHARACTERISTICS AT MR-IMAGING OF THE ELDERLY - DATA FROM THE CARDIOVASCULAR HEALTH STUDY", Radiology, 202(1), 1997, pp. 47-54

Abstract

PURPOSE: To determine the prevalence and anatomic characteristics of infarctlike lesions seen on cranial magnetic resonance (MR) images. MATERIALS AND METHODS: The study cohort consisted of 5,888 community-living individuals aged 65 years and older enrolled in a longitudinal, population-based study of cardiovascular disease. MR images were obtained from 3,658 participants and evaluated by trained readers. Lesion size, anatomic location, and signal intensity were recorded. Infarctlike lesion was defined as a nonmass, hyperintense region on spin-density- and T2- weighted images and, in cerebral white matter and brain stem, a hypointense region on n- weighted images. RESULTS: Infarctlike lesions were depicted on MR images of 1,323 (36%) participants. Eighty-fivepercent (1,128 participants) had lesions 3 mm or larger in maximum dimension, although 70.9% (1,320 of 1,861) of these lesions were 10 mn or less. Lesion prevalence increased with age, especially with lesions 3 mm or larger, which increased from 22.1% (86 of 389) in the 65-69-year age group to 42.9% (88 of 205) in the over-85-year age group (P < .0001). Lesion prevalence was slightly greater in men (497 of 1,527 [32.5%]) than in women (631 of 2,131 [29.6%]), but did not differ betweenblacks and nonblacks. The deep nuclei were the most commonly affectedanatomic sites, with 78.2% (1,451 of 1,856) of lesions. Lesions that involved the cerebrum and posterior fossa accounted for 11.7% (218 of 1,856) and 10.1% (187 of 1,856) of lesions, respectively. CONCLUSION: If the lesions reported in this study indicate cerebrovascular disease, subclinical disease may be more prevalent than clinical disease, andthe prevalence of disease may rise with age. Also, infarctlike lesions have a distinctive anatomic profile.

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Documento generato il 24/11/20 alle ore 13:39:51