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Titolo:
EFFECTS OF DOBUTAMINE AND ENOXIMONE ON TRANSMITRAL AND PULMONARY VENOUS FLOW CHARACTERISTICS IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AFTER CORONARY-ARTERY BYPASS-GRAFTING
Autore:
VROOM MB; VANWEZEL HB; VANDERBRINK RBA; VANDERLEE R; EIJSMAN L; VISSER CA; VANZWIETEN PA;
Indirizzi:
ACAD MED CTR,DEPT ANESTHESIA,MEIBERGDREEF 9 NL-1105 AZ AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of cardiothoracic and vascular anesthesia
fascicolo: 6, volume: 10, anno: 1996,
pagine: 756 - 763
SICI:
1053-0770(1996)10:6<756:EODAEO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSED DOPPLER ECHOCARDIOGRAPHY; CONGESTIVE-HEART-FAILURE; DIASTOLIC FUNCTION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; LOADING CONDITIONS; DISEASED HEART; MITRAL FLOW; RECOVERY; ANESTHESIOLOGIST; PERSPECTIVES;
Keywords:
CORONARY ARTERY SURGERY; IMPAIRED LEFT VENTRICULAR FUNCTION; DOPPLER ECHOCARDIOGRAPHY; TRANSMITRAL FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Vroom et al., "EFFECTS OF DOBUTAMINE AND ENOXIMONE ON TRANSMITRAL AND PULMONARY VENOUS FLOW CHARACTERISTICS IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AFTER CORONARY-ARTERY BYPASS-GRAFTING", Journal of cardiothoracic and vascular anesthesia, 10(6), 1996, pp. 756-763

Abstract

Objectives: To assess the effects of dobutamine and enoximone on transmitral (TMF) and pulmonary venous flow (PVF) characteristics. Design:Prospective and randomized. Setting: A university hospital intensive care unit. Participants: Thirty patients with moderate left ventricular dysfunction after coronary artery bypass grafting (CABG). Interventions: Patients received either dobutamine, 10 mu g/kg/min, or enoximone, 20 mu g/kg/min, for the treatment of a low cardiac index (CI) (<2.2 L/min/m(2)). Measurements and Main Results: Both drugs significantly (p < 0.05) increased CI from 1.91 +/- 0.17 (dobutamine) and 1.97 +/- 0.17 (enoximone) at baseline to 2.86 +/- 0.70 and 2.84 +/- 0.39 L/min/m(2), respectively. Compared with the enoximone (enox)-treated group, the administration of dobutamine (dob) resulted in significantly (p < 0.05) greater increases in mean arterial pressure (dob: 18 +/- 9% v enox: -2 +/- 7%), heart rate (dob: 24 +/- 13% v enox: 3 +/- 5%) and pulmonary artery pressure (dob: 5 +/- 10% v enox: -4 +/- 9%). In contrast, the increase in stroke volume index was significantly less in the dobutamine-treated group (dob: 22 +/- 27% v enox: 41 +/- 21%). The TMF indices, peak E, and peak A wave increased significantly (p < 0.05) after both dobutamine (baseline: 37.3 +/- 6.7 and 41.1 +/- 9.3; max dose: 42.4 +/- 4.3 and 49.0 +/- 10.2 cm/s) and enoximone (baseline: 36.2 +/- 7.5 and 44.2 +/- 10.9; max dose: 40.5 +/- 5.0 and 49.4 +/- 12.1 cm/s) without significantly altering the E/A ratio. Only dobutamine significantly (p < 0.05) decreased isovolumic relaxation time from 109 +/- 24 to 94 +/- 21 ms. There was no significant change in isovolumic relaxation time between the dobutamine (-12% +/- 17%)- and the enoximone (-4% /- 21%)-treated group. PVF recordings demonstrated a significant increase in time velocity integrals of the S wave with both dobutamine (12.2 +/- 3.1 v 13.7 +/- 3.2 cm) and enoximone (11.0 +/- 3.0 v 12.2 +/- 3.2 cm). No changes in the systolic fraction of the PVF were noted. Conclusions: There were no major differences in parameters reflecting diastolic function between the dobutamine and the enoximone-treated groups. Copyright (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:40:49