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Titolo:
AGGRESSIVE CUTANEOUS T-CELL LYMPHOMA ASSO CIATED WITH EPSTEIN-BARR-VIRUS - 2 CASES
Autore:
MOULY F; BACCARD M; RYBOJAD M; LEBBE C; MORINET F; MOREL P;
Indirizzi:
HOP ST LOUIS,DERMATOL SERV,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP ST LOUIS,SERV MICROBIOL VIROL F-75475 PARIS 10 FRANCE
Titolo Testata:
Annales de dermatologie et de venereologie
fascicolo: 9, volume: 123, anno: 1996,
pagine: 574 - 576
SICI:
0151-9638(1996)123:9<574:ACTLAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
FRE
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
F. Mouly et al., "AGGRESSIVE CUTANEOUS T-CELL LYMPHOMA ASSO CIATED WITH EPSTEIN-BARR-VIRUS - 2 CASES", Annales de dermatologie et de venereologie, 123(9), 1996, pp. 574-576

Abstract

Introduction. The factors of prognosis of the cutaneous T-cell lymphomas are less well known as those of the B-cell lymphomas and the role of the Epstein-Barr virus (EBV) is not yet definitively evaluated. Case reports. Two male patients aged 62 and 82 years had a mycosis fungoides with a lethal outcome. The first patient had mutilating facial rumours; the RNA m of EBV and the genome of EBV were demonstrated in the diseased skin. The second patient had an erythrodermic course with enlarged peripheral lymph nodes and circulating Sezary's cells; the genome of EBV was demonstrated by PCR in the diseased skin. Discussion. Therole of the EBV has already been demonstrated in peripheral aggressive T-cell lymphomas. In the mycosis fungoides, the EBV is associated with the lesions in 0 to 32 p. cent according to the published series. EBV associated T-cell lymphomas have a poor survival rate and the EBV infection may be associated with the expression of the multidrug resistant gene-1 (MDR-1) and the risk of a terminal hemophagocytosis. In ourboth patients the presence of the EBV in the lymphocytes of the skin lesions is also an argument in favour of the pathogenic role of the virus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:18:14