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Titolo:
MAPPING OF THE LINEAR ANTIGENIC DETERMINANTS OF THE LEISHMANIA-INFANTUM HSP70 RECOGNIZED BY LEISHMANIASIS SERA
Autore:
QUIJADA L; REQUENA JM; SOTO M; GOMEZ LC; GUZMAN F; PATARROYO ME; ALONSO C;
Indirizzi:
UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC SEVERO OCHOA MADRID 28049 SPAIN UNIV AUTONOMA MADRID,CSIC,CTR BIOL MOLEC SEVERO OCHOA MADRID 28049 SPAIN UNIV EXTREMADURA,FAC VET,DEPT MED & SANIDA ANIM CACERES 10071 SPAIN HOSP SAN JUAN DIOS,INST IMMUNOL BOGOTA COLOMBIA
Titolo Testata:
Immunology letters
fascicolo: 2-3, volume: 52, anno: 1996,
pagine: 73 - 79
SICI:
0165-2478(1996)52:2-3<73:MOTLAD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEIN; TRYPANOSOMA-CRUZI; IMMUNE-RESPONSES; MAJOR IMMUNOGEN; IDENTIFICATION; INDIVIDUALS; CHAGASI;
Keywords:
HSP70; SYNTHETIC PEPTIDE; B-CELL EPITOPE; CANINE LEISHMANIASIS; CHAGAS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
L. Quijada et al., "MAPPING OF THE LINEAR ANTIGENIC DETERMINANTS OF THE LEISHMANIA-INFANTUM HSP70 RECOGNIZED BY LEISHMANIASIS SERA", Immunology letters, 52(2-3), 1996, pp. 73-79

Abstract

Mapping of antigenic determinants of the Leishmania infantum Hsp70 was studied by analysis of the reactivity of sera from dogs with naturalvisceral leishmaniasis against a collection of peptides representing overlapping sequences of the Hsp70. Despite the considerable variationin the immune response among individuals three immunodominant regionswere revealed encompassing residues 241 to 260 (region I), 435 to 469(region II) and from amino acid 601 to the carboxyl-terminal end of the protein (region III). Since anti-peptide H17 antibodies purified from a pool of leishmaniasis sera recognized the L. infantum Hsp70 and since they did not react with the homologous Hsp70s from other trypanosomatids, such as Trypanosoma cruzi, Trypanosoma rangeli and Leishmaniapanamensis, it was concluded that peptide H17 (region I) contains an immunodominant B cell species-specific epitope. Our data indicate, however, that the complete recombinant L. infantum Hsp79 protein cannot be used as a disease-specific tool for serodiagnosis since it is also recognized by the sera from patients with Chagas' disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:15:50