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Titolo:
ZG-1494-ALPHA, A NOVEL PLATELET-ACTIVATING-FACTOR ACETYLTRANSFERASE INHIBITOR FROM PENICILIUM-RUBRUM, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL-ACTIVITY
Autore:
WEST RR; VANNESS J; VARMING AM; RASSING B; BIGGS S; GASPER S; MCKERNAN PA; PIGGOTT J;
Indirizzi:
ZYMOGENETIC,1201 EASTLAKE AVE E SEATTLE WA 98102 NOVO ALLE BAGSVAERD 2880 DENMARK
Titolo Testata:
Journal of antibiotics
fascicolo: 10, volume: 49, anno: 1996,
pagine: 967 - 973
SICI:
0021-8820(1996)49:10<967:ZANPAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELLS; NMR; BIOSYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.R. West et al., "ZG-1494-ALPHA, A NOVEL PLATELET-ACTIVATING-FACTOR ACETYLTRANSFERASE INHIBITOR FROM PENICILIUM-RUBRUM, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL-ACTIVITY", Journal of antibiotics, 49(10), 1996, pp. 967-973

Abstract

A novel inhibitor of platelet-activating factor (PAF) acetyltransferase, an essential enzyme in the remodeling pathway of platelet-activating factor synthesis, was identified by a high throughput screen of natural product extracts of microbial origin. The compound, ZG-1494 alpha, was isolated from an ethyl acetate extract of a culture broth of Penicillium rubrum through bioassay guided fractionation. The structure of ZG-1494 alpha was determined by spectroscopic methods. A key featureof the structure, which is relatively rare among natural products, isthe 5-hydroxy-3-pyrrolin-2-one moiety. A C-13-C-13 INADEQUATE was utilized to unambiguously determine the regiochemistry of this molecule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:47:11