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Titolo:
EVALUATION OF PEROSPIRONE (SM-9018), A NOVEL SEROTONIN-2 AND DOPAMINE-2 RECEPTOR ANTAGONIST, AND OTHER ANTIPSYCHOTICS IN THE CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR MODEL IN RATS
Autore:
ISHIDATOKUDA K; OHNO Y; SAKAMOTO H; ISHIBASHI T; WAKABAYASHI J; TOJIMA R; MORITA T; NAKAMURA M;
Indirizzi:
SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA KU,3-1-98 KASUGADE NAKA OSAKA 554 JAPAN SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA KU OSAKA 554 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 2, volume: 72, anno: 1996,
pagine: 119 - 126
SICI:
0021-5198(1996)72:2<119:EOP(AN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; 5-HT2; SCHIZOPHRENIA; CORTEX; BRAIN;
Keywords:
PEROSPIRONE; ANTIPSYCHOTIC; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Ishidatokuda et al., "EVALUATION OF PEROSPIRONE (SM-9018), A NOVEL SEROTONIN-2 AND DOPAMINE-2 RECEPTOR ANTAGONIST, AND OTHER ANTIPSYCHOTICS IN THE CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR MODEL IN RATS", Japanese Journal of Pharmacology, 72(2), 1996, pp. 119-126

Abstract

We studied the effects of perospirone (SM-9018), a novel serotonin-2 (5-HT2) and dopamine-2 (D-2) receptor antagonist (SDA), on conditionedfear stress (CFS)-induced freezing behavior in rats and compared its actions with those of other antipsychotics. Exposure of rats to the environment previously paired with foot shock induced marked freezing behavior, which was reduced by the anxiolytic diazepam (0.1-3 mg/kg, p.o.) or antidepressants, desipramine and imipramine (10-100 mg/kg, p.o.). Perospirone at 0.3-3 mg/kg, p.o. significantly attenuated the CFS-induced freezing behavior in a dose-dependent manner, while the effect was reduced at the higher dose of 6 mg/kg. Other SDA-type antipsychotics, clozapine (1-30 mg/kg,p.o.) and risperidone (0.03-1 mg/kg,p.o.), and selective 5-HT2 antagonists, ritanserin (0.1-1 mg/kg, p.o.) and ketanserin (0.3-1 mg/kg, p.o.), all reduced the freezing behavior with U-shaped dose-response curves. However, neither conventional antipsychotic, haloperidol (0.1-3 mg/kg, p.o.), chlorpromazine (3-100 mg/kg,p.o.),thioridazine (3-100 mg/kg,p.o.), mosapramine (3-100 mg/kg, p.o.) nor tiapride (30-1000 mg/kg, p.o.) reduced the CFS-induced freezing behavior. In addition, subacute treatment of rats with perospirone (1-10 mg/kg/day) or imipramine (30 mg/kg/day) for 2 weeks prevented the induction of the freezing behavior by CFS. These findings suggest that SDA-type antipsychotics including perospirone are effective for the treatment of mood disturbances such as anxiety and depressive mood associated with schizophrenia and have a broader efficacy profile as compared with the conventional antipsychotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:02:50