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Titolo:
ANALYSIS OF BINDING OF THE 1,25-DIHYDROXYVITAMIN D-3 RECEPTOR TO POSITIVE AND NEGATIVE VITAMIN-D RESPONSE ELEMENTS
Autore:
DARWISH HM; DELUCA HF;
Indirizzi:
UNIV WISCONSIN,DEPT BIOCHEM,420 HENRY MALL MADISON WI 53706 UNIV WISCONSIN,DEPT BIOCHEM MADISON WI 53706
Titolo Testata:
Archives of biochemistry and biophysics
fascicolo: 2, volume: 334, anno: 1996,
pagine: 223 - 234
SICI:
0003-9861(1996)334:2<223:AOBOT1>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUKARYOTIC TRANSCRIPTIONAL ACTIVATORS; STEROID-HORMONE RECEPTORS; RETINOIC ACID RECEPTORS; THYROID-HORMONE; GLUCOCORTICOID RECEPTOR; ESTROGEN-RECEPTOR; GENE-EXPRESSION; DIRECT REPEATS; DIMERIZATION INTERFACES; 24-HYDROXYLASE GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Darwish e H.F. Deluca, "ANALYSIS OF BINDING OF THE 1,25-DIHYDROXYVITAMIN D-3 RECEPTOR TO POSITIVE AND NEGATIVE VITAMIN-D RESPONSE ELEMENTS", Archives of biochemistry and biophysics, 334(2), 1996, pp. 223-234

Abstract

The binding of the 1,25-dihydroxyvitamin D-3 receptor to the vitamin D response elements (VDREs) in the rat osteocalcin (OSC-DRE), mouse osteopontin (MOP-DRE), rat calbindin D-9k (CaBP-DRE), and human parathyroid hormone genes (PTH-DRE) was studied. Binding of VDR to the three positive VDREs is cooperative. The degree of cooperativity is highest with the calbindin VDRE compared with either the OSC-DRE or the MOP-DRE. This cooperativity is largely absent in the case of the negative element, the I?TH-I)RE. The VDR binds in order of decreasing affinity to PTH-I)RE > OSC-DRE = MOP-DRE > CaBP-DRE. Thus, the greatest affinity is associated with the lowest degree of cooperativity. Further study has revealed that the PTH-VDRE actually consists of two repeat elements like all other VDREs and is not a single six-base sequence. A nuclear factor has also been found that binds downstream from the GGTTCA element in the PTH promoter. The binding site of this factor overlaps the PTH-DRE nucleotide sequence. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:23:06