Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PARTNERSHIP BETWEEN DPC4 AND SMAD PROTEINS IN TGF-BETA SIGNALING PATHWAYS
Autore:
LAGNA G; HATA A; HEMMATIBRIVANLOU A; MASSAGUE J;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 ROCKEFELLER UNIV,HOWARD HUGHES MED INST,MOL EMBRYOL LAB NEW YORK NY 10021
Titolo Testata:
Nature
fascicolo: 6603, volume: 383, anno: 1996,
pagine: 832 - 836
SICI:
0028-0836(1996)383:6603<832:PBDASP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESODERM INDUCTION; ACTIVIN-A; XENOPUS; RECEPTOR; EMBRYOS; HOMOLOG; INDUCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G. Lagna et al., "PARTNERSHIP BETWEEN DPC4 AND SMAD PROTEINS IN TGF-BETA SIGNALING PATHWAYS", Nature, 383(6603), 1996, pp. 832-836

Abstract

THE TGF-beta/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors(1) The signal originated by TGF-beta-like moleculesappears to be transduced by a set of evolutionarily conserved proteins known as SMADs, which upon activation directly translocate to the nucleus where they may activate transcription(2), Five SMAD proteins have so far been characterized in vertebrates(1), These factors are related to the mediator of decapentaplegic (dpp) signalling, mothers against dpp (Mad), in Drosophila(3) and to the Sma genes from Caenorhabditiselegans(4). Smad1 and Smad2 have been shown to mimic the effects of BMP and activin, respectively, both in Xenopus and in mammalian cells(2,5-9), whereas Smad3 (a close homologue of Smad2) and the related protein DPC4, a tumour-suppressor gene product(10), mediate TGF-beta actions(11). We report here that DPC4 is essential for the function of Smad1 and Smad2 in pathways that signal mesoderm induction and patterning in Xenopus embryos, as well as antimitogenic and transcriptional responses in breast epithelial cells, DPC4 associates with Smad1 in response to BMP and with Smad2 in response to activin or TGF-beta. DPC4 is therefore a regulated partner of SMADs that function in different signalling pathways of the TGF-beta family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 13:44:16