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Titolo:
IN-VITRO FIBRINOLYSIS AFTER ADDING LOW-DOSES OF PLASMINOGEN ACTIVATORS AND PLASMIN GENERATION WITH AND WITHOUT OXIDATIVE INACTIVATION OF PLASMIN INHIBITORS IN NEWBORNS AND ADULTS
Autore:
RIES M; KLINGE J; RAUCH R; TRUSEN B; ZENKER M; KEUPER H; HARMS D;
Indirizzi:
UNIV ERLANGEN NURNBERG,KLIN & POLIKLIN KINDER & JUGENDLICHE,LOSCHGESTR 15 D-91054 ERLANGEN GERMANY BEHRINGWERKE AG D-3550 MARBURG GERMANY
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 4, volume: 18, anno: 1996,
pagine: 346 - 351
SICI:
1077-4114(1996)18:4<346:IFAALO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COAGULATION SYSTEM; FULL-TERM NEWBORN; DYSFUNCTIONAL PLASMINOGEN; AORTIC THROMBOSIS; ANTITHROMBIN-III; CLOT LYSIS; TISSUE; INFANTS; THROMBOLYSIS; THERAPY;
Keywords:
FIBRINOLYSIS; THROMBOLYTIC THERAPY; NEWBORNS; PLASMINOGEN; ALPHA 2-ANTIPLASMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Ries et al., "IN-VITRO FIBRINOLYSIS AFTER ADDING LOW-DOSES OF PLASMINOGEN ACTIVATORS AND PLASMIN GENERATION WITH AND WITHOUT OXIDATIVE INACTIVATION OF PLASMIN INHIBITORS IN NEWBORNS AND ADULTS", Journal of pediatric hematology/oncology, 18(4), 1996, pp. 346-351

Abstract

Purpose: The aim of this study was to investigate in vitro fibrinolysis after adding low doses of plasminogen activators and to determine the functional role of plasmin inhibitors in newborns and adults. Patients and Methods: We have studied the kinetics of in vitro fibrinolysisafter adding low doses of urokinase (UK) and recombinant tissue plasminogen activator (rt-PA) by use of a microtiter clot lysis assay, Additionally, we have determined plasmin generation with and without oxidative inactivation of plasmin inhibitors in newborns and adults. Results: The 50% lysis time in the clot lysis assay correlated with the activator dose and was significantly shorter in newborns at rt-PA concentrations of <0.21 mu g/ml. When UK was used as an activator, the 50% lysis time was slightly but significantly prolonged in newborns at concentrations of 140-200 IU/ml, whereas we could find lower values (nonsignificant) at 110 and 80 IU/ml. Plasmin generation after oxidative inactivation of plasmin inhibitors was significantly lower in newborns, even when compared with adult plasma, which was diluted 50%. However, in a physiological plasma milieu (containing natural inhibitors), there were no differences in plasmin generation when streptokinase (SK) was used as an activator and only minor differences when UK was used. Conclusions: Our data indicate a more rapid clot lysis at low UK and rt-PA concentrations in newborns despite significantly reduced plasminogen levels. The results of the plasmin generation experiments suggest a diminished effect of plasmin inhibitors towards fetal plasmin, which raises an explanation for the concentration-related differences in the clot lysis assay. The experience with thrombolytic agents in newborns is limited. Most dosage regimens for thrombolytic therapy in children or adults consist of an initial bolus infusion, followed by low-dose continuous treatment. Based on the results of our clot lysis experiments, we think that especially the continuous infusion of plasminogen activators after bolus administration should not be enhanced in newborns compared to older children or adults.

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Documento generato il 26/09/20 alle ore 08:37:25