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Titolo:
OVERVIEW OF CONDITIONING RELATED LIFE-THREATENING TOXICITIES OF MARROW TRANSPLANTATION
Autore:
BEARMAN SI;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,BONE MARROW TRANSPLANT PROGRAM,4200 E 9TH AVE,CAMPUS BOX B-190 DENVER CO 80262
Titolo Testata:
Seminars in respiratory and critical care medicine
fascicolo: 5, volume: 17, anno: 1996,
pagine: 365 - 372
SICI:
1069-3424(1996)17:5<365:OOCRLT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CHEMOTHERAPY; HEPATIC VENOOCCLUSIVE DISEASE; BLOOD PROGENITOR CELLS; TISSUE PLASMINOGEN-ACTIVATOR; INDUCED HEMORRHAGIC CYSTITIS; REGIMEN-RELATED TOXICITIES; COLONY-STIMULATING FACTOR; TOTAL-BODY IRRADIATION; PERIPHERAL-BLOOD; BREAST-CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
S.I. Bearman, "OVERVIEW OF CONDITIONING RELATED LIFE-THREATENING TOXICITIES OF MARROW TRANSPLANTATION", Seminars in respiratory and critical care medicine, 17(5), 1996, pp. 365-372

Abstract

Chemotherapeutic agents used for blood and marrow transplantation areadministered at doses up to 10 times greater than what would be used in conventional treatment of malignancies. This aggressive use of chemotherapy, with or without concomitant radiation, is associated with multiple organ toxicities. Common, and frequently life-threatening toxicities include cardiac toxicity, veno-occlusive disease of the liver, idiopathic pneumonia, neurotoxicity, renal failure, and oral mucositis. Often these toxicities are difficult to distinguish from other treatment-related complications, such as infection. The precise mechanisms of these injuries are poorly understood, but may relate to depletion ofantioxidants. Although preventative strategies do not appear to be particularly effective, prompt recognition of the problems may be life-saving.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 12:53:45