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Titolo:
PSYCHOMOTOR SLOWING IN HIV-INFECTION - A PREDICTOR OF DEMENTIA, AIDS AND DEATH
Autore:
SACKTOR NC; BACELLAR H; HOOVER DR; NANCESPROSON TE; SELNES OA; MILLER EN; DALPAN GJ; KLEEBERGER C; BROWN A; SAAH A; MCARTHUR JC;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21218 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 00000 JOHNS HOPKINS BAYVIEW MED CTR,DEPT NEUROL BALTIMORE MD 00000 UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT LOS ANGELES CA 90024
Titolo Testata:
Journal of neurovirology
fascicolo: 6, volume: 2, anno: 1996,
pagine: 404 - 410
SICI:
1355-0284(1996)2:6<404:PSIH-A>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; NEUROPSYCHOLOGICAL PERFORMANCE; HOMOSEXUAL MEN; FOLLOW-UP; COHORT; MANIFESTATIONS; PROGRESSION; FATIGUE; COMPLEX;
Keywords:
HIV; DEMENTIA; PREDICTOR; PSYCHOMOTOR SLOWING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
N.C. Sacktor et al., "PSYCHOMOTOR SLOWING IN HIV-INFECTION - A PREDICTOR OF DEMENTIA, AIDS AND DEATH", Journal of neurovirology, 2(6), 1996, pp. 404-410

Abstract

The objective of this study was to determine if sustained decline in psychomotor speed tests is associated with an increased risk of progression to dementia, acquired immunodeficiency syndrome (AIDS), or mortality in human immunodeficiency virus (HIV)-1-infected homosexual men in the Baltimore site of the Multicenter AIDS Cohort Study (MACS). Clinical and neuropsychological data were obtained on 291 HIV+ homosexual men seen semi-annually over a nine year period (1986-1994). A proportional hazards model was used to assess the predictive value of sustained psychomotor slowing (defined as a 2.0 standard deviation (s.d.) decline in performance on either the Symbol Digit Modalities test or Trailmaking test at two consecutive evaluations), Time-dependent co-variates included in the model were sustained psychomotor slowing, number of attended visits, CD4(+) lymphocyte count, hemoglobin and antiretroviral medication use. HIV+ participants with and without sustained psychomotor slowing were compared. Outcome variables were the development of dementia, AIDS and death. HIV+ subjects with sustained psychomotor slowing had an increased hazard of dementia (Risk ratio (RR)=5.0, P=0.008), AIDS (RR=2.4, P=0.02), and death (RR=2.0, P=0.04). A similar analysis using sustained cognitive decline in one domain from a more extensive neuropsychological test battery failed to show any predictive value. Sustained decline in psychomotor performance in HIV infection was predictive of dementia, AIDS and death. This brief neuropsychological test battery may be useful for early detection of HIV+ individuals with a poorer prognosis who may benefit from more aggressive treatment to prevent HIV dementia.

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Documento generato il 30/11/20 alle ore 02:29:24