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Titolo:
AGING MECHANISMS IN FRUIT-FLIES
Autore:
TOWER J;
Indirizzi:
UNIV SO CALIF,DEPT BIOL SCI,SHS 172,UNIV PK LOS ANGELES CA 90089 UNIV SO CALIF,SCH GERONTOL LOS ANGELES CA 90089
Titolo Testata:
BioEssays
fascicolo: 10, volume: 18, anno: 1996,
pagine: 799 - 807
SICI:
0265-9247(1996)18:10<799:AMIF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-LIVED STRAIN; ELONGATION-FACTOR EF-1-ALPHA; SUPEROXIDE-DISMUTASE OVEREXPRESSION; TRANSGENIC DROSOPHILA-MELANOGASTER; HEAT-SHOCK PROTEINS; LIFE-SPAN; POSTPONED SENESCENCE; OXIDATIVE STRESS; ADULT DROSOPHILA; ACATALASEMIC MUTANTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
J. Tower, "AGING MECHANISMS IN FRUIT-FLIES", BioEssays, 18(10), 1996, pp. 799-807

Abstract

Genetic analysis of Drosophila has provided evidence in support of two proposed evolutionary genetic mechanisms of aging: mutation accumulation and antagonistic pleiotropy. Both mechanisms result from the lackof natural selection acting on old organisms. Analyses of large numbers of flies have revealed that mortality rates do not continue to risewith age as previously thought, but plateau at advanced ages. This phenomenon has implications both for models and for definitions of aging, and may be explained by the evolutionary theories. The physiologicalprocesses and genes most relevant to aging are being identified usingDrosophila lines selected in the laboratory for postponed senescence. Oxidative stress and insufficient metabolic reserves/capacity may be particularly important factors in limiting the fruitfly lifespan. Genes which exhibit aging-related changes in expression are now being identified. Transgenic flies are being used to analyze the mechanisms of such aging-related gene expression, and to test the effects of specificgenes on aging and aging-related deterioration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:03:57