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Titolo:
MOLECULAR CHARACTERIZATION OF FELINE IMMUNODEFICIENCY VIRUS GENOME OBTAINED DIRECTLY FROM ORGANS OF A NATURALLY INFECTED CAT WITH MARKED NEUROLOGICAL SYMPTOMS AND ENCEPHALITIS
Autore:
NISHIMURA Y; NAKAMURA S; GOTO N; HASEGAWA T; PANG H; GOTO Y; KATO H; YOUN HY; ENDO Y; MIZUNO T; MOMOI Y; OHNO K; WATARI T; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED TOKYO 113 JAPAN UNIV TOKYO,FAC AGR,DEPT VET PATHOL TOKYO 113 JAPAN MIYAZAKI UNIV,FAC AGR,DEPT VET INTERNAL MED MIYAZAKI 88921 JAPAN
Titolo Testata:
Archives of virology
fascicolo: 10, volume: 141, anno: 1996,
pagine: 1933 - 1948
SICI:
0304-8608(1996)141:10<1933:MCOFIV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; NUCLEOTIDE-SEQUENCE; UNITED-STATES; BIOLOGICAL PROPERTIES; MACROPHAGE TROPISM; HOST RANGE; ENV GENE; TYPE-1; BRAIN; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nishimura et al., "MOLECULAR CHARACTERIZATION OF FELINE IMMUNODEFICIENCY VIRUS GENOME OBTAINED DIRECTLY FROM ORGANS OF A NATURALLY INFECTED CAT WITH MARKED NEUROLOGICAL SYMPTOMS AND ENCEPHALITIS", Archives of virology, 141(10), 1996, pp. 1933-1948

Abstract

Feline immunodeficiency virus (FIV) was first isolated from cats withimmunodeficiency syndrome. Recently, neurological abnormalities and brain lesions were shown in cats infected with FIV. To investigate the FIV genome associated with central nervous system (CNS) lesions, proviral DNA sequences from the V3-V6 region of the FIV env gene were directly amplified from uncultured necropsy tissues of a 2-year-old naturally FIV-infected cat with marked neurological symptoms and. encephalitis. By in situ hybridization, FIV RNA was detected mainly in the astrocytes. Fifteen clones isolated from cerebrum, bone marrow and lymph node samples showed only a small number of mutations or deletions in thisreg:ion. A representative clone, JN-BR1, was distantly related to theprevious Japanese strain (TM2) belonging to the subtype B. However, it was relatively close to the Petaluma strain which is known to infectfeline brain-derived culture cells and induce brain lesions in inoculated cats. By phylogenetic analysis, the JN-BR1 strain was placed in subtype A that included Petaluma strain and several other American and European strains. The JN-BR1 strain derived from brain with encephalitis in this study and the Petaluma strain may share a common genetic structure that is related to their neuropathogenicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 22:02:23