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Titolo:
ADVANCED GLYCATION ENDPRODUCTS (AGES) INDUCE OXIDANT STRESS IN THE GINGIVA - A POTENTIAL MECHANISM UNDERLYING ACCELERATED PERIODONTAL-DISEASE ASSOCIATED WITH DIABETES
Autore:
SCHMIDT AM; WEIDMAN E; LALLA E; YAN SD; HORI O; CAO R; BRETT JG; LAMSTER IB;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,SCH DENT & ORAL SURG,DEPT SURG,P&S 11-518,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH DENT & ORAL SURG,DEPT MED NEW YORKNY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH DENT & ORAL SURG,DEPT PHYSIOL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH DENT & ORAL SURG,DIV PERIODONT NEWYORK NY 10032
Titolo Testata:
Journal of Periodontal Research
fascicolo: 7, volume: 31, anno: 1996,
pagine: 508 - 515
SICI:
0022-3484(1996)31:7<508:AGE(IO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSYLATION END-PRODUCTS; CELL-ADHESION MOLECULE-1; NF-KAPPA-B; MATRIX METALLOPROTEINASES; INFLAMMATORY MEDIATORS; LIPID-PEROXIDATION; IN-VIVO; EXPRESSION; RECEPTOR; PROTEIN;
Keywords:
GLYCATION; OXIDATION; DIABETES; PERIODONTUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Schmidt et al., "ADVANCED GLYCATION ENDPRODUCTS (AGES) INDUCE OXIDANT STRESS IN THE GINGIVA - A POTENTIAL MECHANISM UNDERLYING ACCELERATED PERIODONTAL-DISEASE ASSOCIATED WITH DIABETES", Journal of Periodontal Research, 31(7), 1996, pp. 508-515

Abstract

We hypothesizes that one mechanism underlying advanced periodontal disease in diabetes may involve oxidant stress in the gingiva, induced by the effects of Advanced Glycation Endproducts (AGE5), the irreversible products of non-enzymatic glycation and oxidation of proteins and lipids which accumulate in diabetic plasma and tissue: Infusion of AGE albumin, a prototypic ligand, into mice resulted in increased generation of thiobarbituric acid reactive substances (TEARS) compared with infusion of non-glycated albumin in the gingiva: as well as in the lung,kidney and brain. Pretreatment of the animals with the antioxidants probucol or N-acetylcysteine (NAC) prevented the generation of TEARS inthe gingiva. Affinity-purified antibody to AGEs demonstrated increased immunoreactivity for AGEs in the vasculature and connective tissues of the gingiva in streptozotocin-induced diabetic mice compared to non-diabetic controls. Increased immunoreactivity for AGEs was also demonstrated in the gingiva of diabetic humans compared with non-diabetic individuals via immunohistochemistry and ELISA. Consistent with these,data, immunohistochemistry for heme oxygenase-1, a masker of enhanced oxidant stress, was increased in the gingival vasculature of diabetic mice and humans compared with non-diabetic controls. These data suggestthat AGEs present in. diabetic gingiva may be associated with a stateof enhanced oxidant stress, a potential mechanism for accelerated tissue injury.

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Documento generato il 24/09/20 alle ore 07:43:42