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Titolo:
INHIBITION OF DIAMINE OXIDASE PROMOTES UPTAKE OF PUTRESCINE FROM RAT SMALL-INTESTINE
Autore:
NILSSON BO; KOCKUM I; ROSENGREN E;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & NEUROSCI,SOLVEGATAN 19 S-22362 LUND SWEDEN
Titolo Testata:
Inflammation research
fascicolo: 10, volume: 45, anno: 1996,
pagine: 513 - 518
SICI:
1023-3830(1996)45:10<513:IODOPU>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYAMINE METABOLISM; CELLS; CATABOLISM; HISTAMINE; ISCHEMIA; MUCOSA; BLOOD;
Keywords:
DIAMINE OXIDASE; HISTAMINE; PUTRESCINE; SMALL INTESTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B.O. Nilsson et al., "INHIBITION OF DIAMINE OXIDASE PROMOTES UPTAKE OF PUTRESCINE FROM RAT SMALL-INTESTINE", Inflammation research, 45(10), 1996, pp. 513-518

Abstract

In blood from the portal vein of anaesthetized rats the levels of histamine and putrescine were 2-3-fold lower compared to arterial blood. Putrescine concentration was increased severalfold and the difference between portal and arterial blood abolished in animals pretreated withthe specific diamine oxidase inhibitor aminoguanidine. Histamine concentration was 40% lower in portal compared to arterial blood in animals treated with the mast cell degranulator compound 48/80. In animals pretreated with aminoguanidine, compound 48/80 enhanced the level of histamine and no difference was observed between arterial and portal blood. The amounts of intravenously injected [C-14]-labeled histamine wasabout 15% lower in portal compared to arterial blood. The uptake of [C-14]-putrescine from the small intestine was estimated. In urine fromanimals retreated with aminoguanidine the concentration of [C-14]-putrescine was more than 40-times higher than in control animals corresponding to a calculated uptake of about 7% in aminoguanidine treated animals. Our results suggest that intestinal diamine oxidase clears the blood from diamines and prevents luminal uptake of putrescine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:19:43