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Titolo:
INTERVENTION OF CRESCENTIC GLOMERULONEPHRITIS BY ANTIBODIES TO MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR (MCAF MCP-1)/
Autore:
WADA T; YOKOYAMA H; FURUICHI K; KOBAYASHI KI; HARADA K; NARUTO M; SU SB; AKIYAMA M; MUKAIDA N; MATSUSHIMA K;
Indirizzi:
KANAZAWA UNIV,CANC RES INST,DEPT PHARMACOL,13-1 TAKARA MACHI KANAZAWAISHIKAWA 920 JAPAN KANAZAWA UNIV,CANC RES INST,DEPT PHARMACOL KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 1 KANAZAWA ISHIKAWA 920 JAPAN TORAY INDUSTRIES LTD,BASIC RES LABS KAMAKURA KANAGAWA JAPAN
Titolo Testata:
The FASEB journal
fascicolo: 12, volume: 10, anno: 1996,
pagine: 1418 - 1425
SICI:
0892-6638(1996)10:12<1418:IOCGBA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; CHEMOATTRACTANT PROTEIN-1; MESANGIAL CELLS; EXPRESSION; NEPHRITIS; RAT; INTERLEUKIN-8; PROLIFERATION; PURIFICATION; PEPTIDE-1;
Keywords:
CHEMOKINE; GLOMERULAR BASE MEMBRANE; MACROPHAGE; PROTEINURIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Wada et al., "INTERVENTION OF CRESCENTIC GLOMERULONEPHRITIS BY ANTIBODIES TO MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR (MCAF MCP-1)/", The FASEB journal, 10(12), 1996, pp. 1418-1425

Abstract

We investigated the pathophysiological cole of a potent macrophage (Mphi) chemotactic cytokine (chemokine), monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), in an animal model of crescentic glomerulonephritis. Administration of a smalldose of nephrotoxic sera induced severe proliferative and necrotizingglomerulonephritis, with crescentic formation in the early phase and glomerulosclerosis in the later phase, in Wistar-Kyoto rats. MCAF/MCP-1 protein was detected immunohistochemic ally in glomeruli, vascular endothelial cells, and tubular epithelial cells in the early phase of injured kidney tissues but not in normal ones. Anti-MCAF/MCP-1 antibodies decreased the number of M phi in glomeruli, and prevented crescentic formation and the fusion of epithelial cell foot process in nephritic rats, thereby decreasing the excreted amounts of protein to normal levels on days 3 and 6. Furthermore, anti-MCAF/MCP-1 antibodies remarkably reduced glomerulosclerosis and improved renal dysfunction as well as proteinuria in the later phase (56 days). These results indicate that MCAF/MCP-1 essentially participates in the impairment of renal functions associated with crescentic glomerulonephritis by recruiting and activating M phi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:15:59