Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MESENTERIC AND HEPATIC VASCULAR REACTIVITY IN DONRYU RATS WITH AND WITHOUT A CHOLESTEROL-SUPPLEMENTED DIET
Autore:
RALEVIC V; ALIEV G; BURNSTOCK G;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,GOWER ST LONDON WC1E 6BT ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 313, anno: 1996,
pagine: 221 - 227
SICI:
0014-2999(1996)313:3<221:MAHVRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; HYPERLIPIDEMIC YOSHIDA RATS; ATHEROSCLEROTIC MONKEYS; CORONARY-ARTERIES; THORACIC AORTA; SYMPATHETIC NEUROTRANSMISSION; HYPERCHOLESTEROLEMIC RABBITS; AGGREGATING PLATELETS; WHHL RABBITS; ANIMAL-MODEL;
Keywords:
CHOLESTEROL-FEEDING; ENDOTHELIUM; P-2X PURINOCEPTOR; MESENTERIC ARTERIAL BED, RAT; SYMPATHETIC NEUROTRANSMISSION; DONRYU RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
V. Ralevic et al., "MESENTERIC AND HEPATIC VASCULAR REACTIVITY IN DONRYU RATS WITH AND WITHOUT A CHOLESTEROL-SUPPLEMENTED DIET", European journal of pharmacology, 313(3), 1996, pp. 221-227

Abstract

Vascular function of Donryu rats fed on a normal or cholesterol-supplemented diet was examined in the isolated perfused mesenteric arterialbed and portally perfused liver. In mesenteric preparations, frequency-dependent vasoconstriction to electrical field stimulation (4-32 Hz,1 ms, 90 V, 30 s) and dose-dependent vasoconstriction to noradrenaline (0.15-1500 nmol) was similar in both groups. Dose-dependent vasoconstriction to alpha,beta-methylene ATP (0.05-500 nmol) via P-2X purinoceptors was significantly impaired in Donryu rats fed on a cholesterol-supplemented diet. In preparations with raised tone (methoxamine 5-35 mu M), there was no significant difference in endothelium-dependent relaxation to acetylcholine and ATP, or endothelium-independent relaxation to sodium nitroprusside. In liver preparations, there was no difference in frequency-dependent vasoconstriction to electrical field stimulation (2-32 Hz, 1 ms, 90 V, 30 s), or dose-dependent vasoconstriction to noradrenaline (0.05-500 nmol) and alpha,beta-methylene ATP (0.05-500 nmol) between the groups. In conclusion, in mesenteric arteries, butnot in the hepatic portal vasculature of Donryu rats fed on cholesterol P-2X purinoceptor function is impaired, but sympathetic neurotransmission is unaffected. Mesenteric endothelial and smooth muscle function is unimpaired.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:42:41