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Titolo:
NERVE FUNCTION AND BLOOD-FLOW IN OTSUKA-LONG EVANS-TOKUSHIMA FATTY RATS WITH SUCROSE FEEDING - EFFECT OF AN ANTICOAGULANT
Autore:
HOTTA N; KOH N; SAKAKIBARA F; NAKAMURA J; HAMADA Y; HARA T; MORI K; NARUSE K; FUKASAWA H; KAKUTA H; SAKAMOTO N;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 3,SHOWA KU,65 TSURUMO CHO NAGOYA AICHI 466 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 313, anno: 1996,
pagine: 201 - 209
SICI:
0014-2999(1996)313:3<201:NFABIO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DIABETIC RATS; ADENOSINE-TRIPHOSPHATASE-ACTIVITY; ALDOSE REDUCTASE INHIBITOR; CONDUCTION-VELOCITY; PERIPHERAL-NERVE; SCIATIC-NERVE; NEUROPATHY; PREVENTION; CILOSTAZOL; MOTOR;
Keywords:
CILOSTAZOL; OTSUKA LONG-EVANS TOKUSHIMA FATTY RAT; MOTOR NERVE CONDUCTION VELOCITY; R-R INTERVAL, COEFFICIENT OF VARIATION; SCIATIC NERVE BLOOD FLOW; PLATELET AGGREGATION; 2,3-DIPHOSPHOGLYCERATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N. Hotta et al., "NERVE FUNCTION AND BLOOD-FLOW IN OTSUKA-LONG EVANS-TOKUSHIMA FATTY RATS WITH SUCROSE FEEDING - EFFECT OF AN ANTICOAGULANT", European journal of pharmacology, 313(3), 1996, pp. 201-209

Abstract

To investigate the pathogenesis of diabetic neuropathy in non-insulin-dependent diabetes mellitus, Otsuka Long-Evans Tokushima Fatty rats, an animal model of non-insulin-dependent diabetes mellitus, and non-diabetic Long-Evans Tokuskima Otsuka rats were fed with or without sucrose and/or cilostazol, an anticoagulant, for 8 weeks. Sucrose-fed diabetic rats showed a delayed motor nerve conduction velocity, decreased R-R interval variability of electrocardiogram, reduced sciatic nerve blood flow, increased platelet aggregability and a decreased erythrocyte2,3-diphosphoglycerate concentration compared with non-sucrose-fed diabetic rats and non-diabetic rats. These abnormalities were significantly prevented by treatment with cilostazol without changes in the nerve tissue levels of polyols. These findings indicate that sucrose-fed Otsuka Long-Evans Tokushima Fatty rats may be a useful animal model of neuropathy in non-insulin-dependent diabetes mellitus, and that cilostazol may prevent the development of diabetic neuropathy by modifying vascular factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:01:03