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Titolo:
NEURAL SENSITIZATION AND PHYSIOLOGICAL MARKERS IN MULTIPLE CHEMICAL-SENSITIVITY
Autore:
BELL IR; SCHWARTZ GE; BALDWIN CM; HARDIN EE;
Indirizzi:
VET AFFAIRS MED CTR,DEPT PSYCHIAT,MAIL STOP 116A,3601 S 6TH AVE TUCSON AZ 85723 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85721 UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85721 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 85721 UNIV ARIZONA,DEPT NEUROL TUCSON AZ 85721 UNIV ARIZONA,DIV RESP SCI TUCSON AZ 85721
Titolo Testata:
Regulatory toxicology and pharmacology
fascicolo: 1, volume: 24, anno: 1996,
parte:, 2
pagine: 39 - 47
SICI:
0273-2300(1996)24:1<39:NSAPMI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-REPORTED ILLNESS; TIME-DEPENDENT SENSITIZATION; SEASONAL AFFECTIVE-DISORDER; BEHAVIORAL SENSITIZATION; ENVIRONMENTAL ILLNESS; NUCLEUS-ACCUMBENS; ORGANIC-SOLVENTS; PANIC DISORDER; YOUNG-ADULTS; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Bell et al., "NEURAL SENSITIZATION AND PHYSIOLOGICAL MARKERS IN MULTIPLE CHEMICAL-SENSITIVITY", Regulatory toxicology and pharmacology, 24(1), 1996, pp. 39-47

Abstract

This paper summarizes the key features of the olfactory-limbic, neural sensitization model for multiple chemical sensitivity (MCS) and presents relevant data on chemically intolerant human subjects from laboratory studies using quantitative electroencephalography, polysomnography, neuropsychological tests, cardiovascular measurements, and blood markers, MCS is a poorly understood chronic, polysymptomatic condition in which some prior controlled research studies have failed to find evidence to differentiate active from placebo tests. Closer examination of past MCS research, however, reveals that studies have failed to incorporate the design and methodological approaches necessary to test fornonimmunological sensitization. Time-dependent sensitization (TDS) isa well-documented phenomenon in the pharmacology literature involvingthe progressive increase in a given response by the passage of time between the initial and subsequent exposures to a substance or a stressor. As in MCS, multiple, chemically unrelated agents can trigger TDS. Females time-sensitize more readily than do males. pharmacological andnonpharmacological (stress) stimuli can cross-sensitize. Dopaminergicpathways in the brain and the hypothalamic-pituitary-adrenal axis arelikely involved in TDS. Data on the symptomatology of MCS point to central nervous system involvement, including limbic regions that receive input from both olfactory (odor) and trigeminal (irritant) pathways,Limbic and mesolimbic brain regions are among the most sensitizable to repeated, intermittent environmental stimuli. Sensitizable individuals can show no difference or lesser responses to a test substance on initial exposure, but later exhibit much greater increases in responsivity on the next exposure after a period of days. For future research, it is essential to distinguish chemical intolerance symptoms such as derealization, sudden mood changes, musculoskeletal pain, menstrual dysfunction, and uncontrollable sleepiness from chemical phobia and avoidance behaviors. This model permits hypothesis-driven research on MCS and has major implications for interpretation of apparently positive and negative tests for ''true'' as opposed to ''perceived'' sensitivity to low levels of environmental chemicals. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:57:00