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Titolo:
HUMAN EXPOSURE TO MERCURY - A CRITICAL-ASSESSMENT OF THE EVIDENCE OF ADVERSE HEALTH-EFFECTS
Autore:
RATCLIFFE HE; SWANSON GM; FISCHER LJ;
Indirizzi:
MICHIGAN STATE UNIV,CTR CANC,A128 E FEE HALL E LANSING MI 48824 MICHIGAN STATE UNIV,CTR CANC E LANSING MI 48824 MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL E LANSING MI 48824
Titolo Testata:
Journal of toxicology and environmental health
fascicolo: 3, volume: 49, anno: 1996,
pagine: 221 - 270
SICI:
0098-4108(1996)49:3<221:HETM-A>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILVER DENTAL FILLINGS; LONG-TERM EXPOSURE; LOW-DOSE EXPOSURE; ELEMENTAL MERCURY; OCCUPATIONAL EXPOSURE; INORGANIC MERCURY; METHYL MERCURY; CHLORALKALI WORKERS; MINAMATA DISEASE; FISH CONSUMPTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
258
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Ratcliffe et al., "HUMAN EXPOSURE TO MERCURY - A CRITICAL-ASSESSMENT OF THE EVIDENCE OF ADVERSE HEALTH-EFFECTS", Journal of toxicology and environmental health, 49(3), 1996, pp. 221-270

Abstract

The ubiquitous nature of mercury in the environment, its global atmospheric cycling, and its toxicity to humans at levels that are uncomfortably close to exposures experienced by a proportion of the populationare some of the current concerns associated with this pollutant. The purpose of this review is to critically evaluate the scientific quality of published reports involving human exposures to mercury and associated health outcomes as an aid in the risk evaluation of this chemical. A comprehensive review of the scientific literature involving human exposures to mercury was performed and each publication evaluated using a defined set of criteria that are considered standards in epidemiologic and toxicologic research. Severe, sometimes fatal, effects of mercury exposure at high levels were primarily reported as case studies. The disasters in Minamata, japan, in the 1950s and in Iraq in 1971-1972 clearly demonstrated neurologic effects associated with ingestion ofmethylmercury both in adults and in infants exposed in utero. The effects were convincingly associated with methylmercury ingestion, despite limitations of the study design. Several well-conducted studies haveinvestigated the effects of methylmercury at levels below those in the Iraq incident but have not provided clear evidence of an effect. Thelower end of the dose-response curve constructed from the iraq data therefore still needs to be confirmed. The studies of mercury exposure in the workplace were mainly of elemental or inorganic mercury, and effects that were observed at relatively low exposure levels were primarily neurologic and renal. Several studies have investigated effects associated with dental amalgam but have been rated as inconclusive because of methodologic deficiencies. In our overall evaluation, 29 of 110 occupational studies and 20 of 54 studies where exposure occurred in the natural environment provided at least suggestive evidence of an exposure-related effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:01:59