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Titolo:
P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY ON CHANGES IN PHOSPHOCREATINE AND THE INTRACELLULAR PH IN RAT SKELETAL-MUSCLE DURING EXERCISE AT VARIOUS INSPIRED OXYGEN CONTENTS
Autore:
SUNOO S; ASANO K; MITSUMORI F;
Indirizzi:
NATL INST ENVIRONM STUDIES,ONOGAWA 16-2 TSUKUBA IBARAKI 305 JAPAN NATL INST ENVIRONM STUDIES TSUKUBA IBARAKI 305 JAPAN UNIV TSUKUBA,INST HLTH & SPORTS SCI,EXERCISE PHYSIOL LAB TSUKUBA IBARAKI 305 JAPAN
Titolo Testata:
European journal of applied physiology and occupational physiology
fascicolo: 4, volume: 74, anno: 1996,
pagine: 305 - 310
SICI:
0301-5548(1996)74:4<305:PNSOCI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENERGY-METABOLISM; CREATINE-KINASE; ANDEAN NATIVES; ATP TURNOVER; LACTATE; SPECTROSCOPY; DEPENDENCE; RECOVERY; HYPOXIA;
Keywords:
P-31 NUCLEAR MAGNETIC RESONANCE; HYPOXIC EXERCISE; PHOSPHOCREATINE; INTRACELLULAR PH; OXYGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Sunoo et al., "P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY ON CHANGES IN PHOSPHOCREATINE AND THE INTRACELLULAR PH IN RAT SKELETAL-MUSCLE DURING EXERCISE AT VARIOUS INSPIRED OXYGEN CONTENTS", European journal of applied physiology and occupational physiology, 74(4), 1996, pp. 305-310

Abstract

We measured ATP, phosphocreatine (PCr), inorganic phosphate (P-i), and the intracellular pH in rat hindlimb muscles during submaximal isometric exercise with various O-2 deliveries using P-31 nuclear magnetic resonance spectroscopy (P-31 NMR) to evaluate changes in energy metabolism in relation to O-2 availability. Delivery of O-2 to muscles was altered by controlling the fractional concentration of inspired oxygen (FIO2) at 0.50, 0.28, 0.21, 0.11 and 0.08 with monitoring partial pressure of oxygen and carbon dioxide, and bicarbonate at the femoral artery. The steady-state ratio of PCr : (PCr + P-i) during exercise decreased as a function of FIO2 even at 0.21. Significant acidification of the intracellular pH during exercise occurred at 0.08 FIO2. Change in the PCr: (PCr + P-i) ratio demonstrated that the oxidative capacity, i.e. the maximal rate of the oxidative phosphorylation reaction, in muscle was not limited by O-2 delivery at 0.50 FIO2, but was significantlylimited at 0.21 FIO2 or below. Change in the intracellular pH at 0.08FIO2 could be interpreted as an increase in lactate, suggesting activation of glycolysis. Correlation between the PCr:(PCr + P-i) ratio andthe intracellular pH revealed the existence of a critical PCr : (PCr P-i) ratio and pH for glycolysis activation at around 0.4 and 6.7, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:23:00