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Titolo:
ADVANCES IN THE TREATMENT OF SCHIZOPHRENIA
Autore:
KUPERBERG GR;
Indirizzi:
INST PSYCHIAT,DEPT PSYCHOL MED,DECRESPIGNY PK,DENMARK HILL LONDON SE58AF ENGLAND MAUDSLEY HOSP & INST PSYCHIAT LONDON SE5 8AZ ENGLAND
Titolo Testata:
British journal of clinical practice
fascicolo: 6, volume: 50, anno: 1996,
pagine: 315 - 323
SICI:
0007-0947(1996)50:6<315:AITTOS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON-EMISSION TOMOGRAPHY; TREATMENT-REFRACTORY SCHIZOPHRENICS; D2-DOPAMINE RECEPTOR OCCUPANCY; A9 DOPAMINE NEURONS; NEGATIVE SYMPTOMS; ANTIPSYCHOTIC-DRUGS; CASE-MANAGEMENT; MAINTENANCE THERAPY; CLOZAPINE TREATMENT; EARLY INTERVENTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
189
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Kuperberg, "ADVANCES IN THE TREATMENT OF SCHIZOPHRENIA", British journal of clinical practice, 50(6), 1996, pp. 315-323

Abstract

We review advances in the treatment of schizophrenia. We begin with an overview of antipsychotic drug development, focusing on the in vitroand in vivo binding profiles of clozapine and a new generation of D2:5HT antagonists. We then consider the main barriers to effective treatment: non-compliance (and side-effects) of medication, recurrent relapse, 'treatment resistance', negative symptoms and neurocognitive deficits. Within this framework, we review the mechanisms of action and clinical uses of the 'atypical' antipsychotic drugs. We also show how a variety of psychosocial interventions, particularly those that incorporate cognitive techniques, can be used in combination with pharmacotherapy to overcome the same clinical hurdles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:22:08