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Titolo:
COMPARATIVE EFFICACY AND TOLERABILITY OF 2 DICLOFENAC FORMULATIONS INTHE TREATMENT OF PAINFUL OSTEOARTHRITIS
Autore:
BAKSHI R;
Indirizzi:
CIBA GEIGY AG,DEPT MED CH-4002 BASEL SWITZERLAND
Titolo Testata:
British journal of clinical practice
fascicolo: 6, volume: 50, anno: 1996,
pagine: 294 - 297
SICI:
0007-0947(1996)50:6<294:CEATO2>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; OSTEO-ARTHRITIS; MODERATE; KNEE; HIP; MG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
R. Bakshi, "COMPARATIVE EFFICACY AND TOLERABILITY OF 2 DICLOFENAC FORMULATIONS INTHE TREATMENT OF PAINFUL OSTEOARTHRITIS", British journal of clinical practice, 50(6), 1996, pp. 294-297

Abstract

The efficacy and tolerability of a new resinate formulation of diclofenac 75mg taken once or twice daily were compared with that of conventional enteric-coated diclofenac sodium 50mg tablets given two or threetimes daily in a double-blind, randomised, between-patient, 12-week trial in 216 adult patients suffering from painful osteoarthritis of the hip and/or knee. Similar and clinically significant reductions in the mean intensity scores of pain at rest or on activity were observed after treatment with either formulation. Global evaluations showed the overall response rate to range between 60% and 75%. A significant analgesic effect was obtained within two weeks of treatment with 150mg diclofenac daily; this improvement was maintained on reduction of the dosage to 75-100mg over the next ten weeks. One or more drug-related adverse events, predominantly gastrointestinal adverse events, were reported by 40% and 38% of patients in the diclofenac resinate and diclofenac sodium groups, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:36:23