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Titolo:
VISCOELASTIC MECHANISMS OF AORTIC BARORECEPTOR RESETTING TO HYPOTENSION AND TO HYPERTENSION
Autore:
XAVIERNETO J; MOREIRA ED; KRIEGER EM;
Indirizzi:
UNIV SAO PAULO,FAC MED,INST CORACAO,UNIDADE HIPERTENSAO,RUA DR ENEAS CARVALHO AGUIAR 44 BR-05403000 SAO PAULO BRAZIL UNIV SAO PAULO,FAC MED,INST CORACAO,UNIDADE HIPERTENSAO BR-05403000 SAO PAULO BRAZIL
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 40, anno: 1996,
pagine: 1407 - 1415
SICI:
0363-6135(1996)40:4<1407:VMOABR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID-SINUS BARORECEPTORS; SMOOTH-MUSCLE TONE; CALIBER CHANGES; TIME COURSE; SHORT-TERM; WALL; RAT; PRESSURE; RABBITS; INVITRO;
Keywords:
VISCOELASTICITY; BARORECEPTOR ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J. Xavierneto et al., "VISCOELASTIC MECHANISMS OF AORTIC BARORECEPTOR RESETTING TO HYPOTENSION AND TO HYPERTENSION", American journal of physiology. Heart and circulatory physiology, 40(4), 1996, pp. 1407-1415

Abstract

Viscoelastic and electrophysiological mechanisms have been implicatedin the resetting of baroreceptors in hypertension, but resetting in response to hypotension has been less studied. To evaluate the temporalrelationship between viscoelastic mechanisms and acute resetting, we examined the ''in vivo'' behavior of aortic caliber and aortic baroreceptor activity during step changes in pressure. Fifteen-minute hemorrhage in Wistar rats produced stable hypotension (30 mmHg) and viscoelastic contraction (111 +/- 14.2 mu m systolic caliber; P < 0.01). Integrated aortic activity fell to 19.8 +/- 3.9% of control (P < 0.001) after 3 s of hypotension but recovered to 64 +/- 4.1% 15 min later (P < 0.01 from 3 s). Recovery of baroreceptor activity was linearly correlated to viscoelastic contraction (r = 0.963; P < 0.0001). Thirty-minute phenylephrine infusion (1.0-4.0 mu g/min) produced stable hypertension (30 mmHg) and viscoelastic dilation (211 +/- 37.0 mu m systolic caliber). Integrated aortic activity increased to 218.0 +/- 18% of control values (P < 0.001) 30 s after hypertension and was reduced to 164.0 +/-12.0% (P < 0.001 from 3 s) within 30 min. Reduction of baroreceptor activity correlated Linearly with viscoelastic relaxation (r = 0.963; P< 0.0001). The results indicate that in the in vivo rat aorta, viscoelastic mechanisms parallel and may contribute to the baroreceptor resetting during hypotension and hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:10:40