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Titolo:
RESPONSES OF MEDULLARY RETICULAR-FORMATION NEURONS TO INPUT FROM THE MALE GENITALIA
Autore:
HUBSCHER CH; JOHNSON RD;
Indirizzi:
UNIV FLORIDA,COLL VET MED,DEPT PHYSIOL SCI,BOX 100144 GAINESVILLE FL 32610 UNIV FLORIDA,COLL VET MED,DEPT PHYSIOL SCI GAINESVILLE FL 32610 UNIV FLORIDA,INST BRAIN GAINESVILLE FL 32610
Titolo Testata:
Journal of neurophysiology
fascicolo: 4, volume: 76, anno: 1996,
pagine: 2474 - 2482
SICI:
0022-3077(1996)76:4<2474:ROMRNT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMBAR BACK MUSCLES; ADULT MALE-RATS; SPINAL-CORD; FEMALE RATS; NUCLEUS PARAGIGANTOCELLULARIS; PENILE MECHANORECEPTORS; DESCENDING PROJECTIONS; VENTROLATERAL MEDULLA; SEXUAL REFLEXES; GLANS PENIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Hubscher e R.D. Johnson, "RESPONSES OF MEDULLARY RETICULAR-FORMATION NEURONS TO INPUT FROM THE MALE GENITALIA", Journal of neurophysiology, 76(4), 1996, pp. 2474-2482

Abstract

1. The medullary reticular formation (MRF) is known to be involved inthe modulation of certain reproductive behaviors. Ejaculation in the male, disrupted after spinal transection, may depend on a spinal-bulbo-spinal connection. To determine whether single neurons in the MRF receive sensory input from the male genitalia, the present study was undertaken using electrophysiological techniques. 2. The MRF of 14 urethan-anesthetized mature male rats was searched for single neurons responsive to bilateral electrical stimulation of the dorsal nerve of the penis (DNP). In addition, each DNP-responsive neuron was tested for responsiveness to bilateral electrical stimulation of the pelvic nerve (PN)and to mechanical stimulation (gentle touch, pressure, pinch) of the external genitalia, anus, urethra, and skin over most regions of the body. 3. A total of 165 single neurons responsive to bilateral electrical stimulation of the DNP were isolated and characterized throughout the MRF. All neurons responded to both ipsilateral and contralateral DNP stimulation. The majority of responses were excitatory, and most neurons had no background activity. Some neurons required wind-up with bilateral electrical stimulation of the DNP to respond. 4. About half ofthe neurons were located in the nucleus reticularis gigantocellularis(Gi); the remainder were located in surrounding (dorsal, ventral, lateral) regions of the MRF. Variations in response properties were foundamong neurons located in different MRF regions. 5. Eighty-eight DNP-responsive neurons were additionally responsive to bilateral electricalstimulation of the PN. None of the responses to bilateral PN were stronger than those for bilateral DNP and many (48%) were weaker. 6. Of the 165 DNP-responsive neurons, all were responsive to pressure/pinching of the penis; 16% responded to gentle stroking of the glans. Most ofthese neurons were additionally responsive (bilaterally) to pinching more than one (often all) of the following areas: perineum, scrotum, anus, ears, and toes (forefoot and hindfoot). 7. In conclusion, neuronslocated in the MRF of male rats are involved in the processing of bilaterally convergent inputs from multiple cutaneous and visceral regions of the body, including the penis and male urogenital tract. These neurons likely exert their effects by directly and/or indirectly activating ascending pathways to rostral regions of the brain important for somatovisceral sensation and motor behavior, and descending pathways tothe spinal cord for modulation of segmental sexual reflexes. Contributions are likely for a wide spectrum of sensations and reproductive behaviors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:32:58