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Titolo:
NATURAL IGA-ANTI-F(AB')(2)GAMMA AUTOANTIBODY OCCURRING IN HEALTHY-INDIVIDUALS AND KIDNEY GRAFT RECIPIENTS RECOGNIZES AN IGG1 HINGE REGION EPITOPE
Autore:
TERNESS P; NAVOLAN D; MORODER L; SIEDLER F; WEYHER E; KOHL I; DUFTER C; WELSCHOF M; DRUGARIN D; SCHNEIDER F; OPELZ G;
Indirizzi:
UNIV HEIDELBERG,INST IMMUNOL,DEPT TRANSPLANTAT IMMUNOL,INF 305 D-69120 HEIDELBERG GERMANY MAX PLANCK INST BIOCHEM D-8033 MARTINSRIED GERMANY UNIV MED & PHARM,DEPT PHYSIOL TIMISOARA ROMANIA
Titolo Testata:
The Journal of immunology
fascicolo: 9, volume: 157, anno: 1996,
pagine: 4251 - 4257
SICI:
0022-1767(1996)157:9<4251:NIAOIH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-FAB AUTOANTIBODIES; FULLY SYNTHETIC IMMUNOGENS; ANTIIDIOTYPIC ANTIBODIES; IDIOTYPIC ANTIBODIES; HLA ANTIBODIES; GASTRIN-I; PEPTIDE; SECONDARY; FRAGMENT; SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Terness et al., "NATURAL IGA-ANTI-F(AB')(2)GAMMA AUTOANTIBODY OCCURRING IN HEALTHY-INDIVIDUALS AND KIDNEY GRAFT RECIPIENTS RECOGNIZES AN IGG1 HINGE REGION EPITOPE", The Journal of immunology, 157(9), 1996, pp. 4251-4257

Abstract

Natural anti-IgG autoantibodies are found both in healthy individualsand in patients with certain diseases, One group of these Abs recognizes epitopes located in the F(ab')(2) region of the IgG molecule. The immunoregulatory role of these Abs in healthy individuals, graft rejection, and disease was previously studied, usually with a focus on the characterization of anti-idiotypic Abs, In the present study, we characterize the epitope recognized by an anti-F(ab')(2) gamma autoantibodyof the IgA isotype, which occurs in the serum of healthy individuals and kidney transplant recipients, The autoantibody described herein reacts strongly with F(ab')(2) gamma but only poorly with Fab gamma fragments, a binding pattern pointing to an epitope located in the hinge region, Using synthetic peptides, we identified a conformational epitope that overlaps the middle and part of the lower hinge region. Structural analyses of peptide constructs showed that a defined conformation of the first three residues of the lower hinge is required for a full expression of the epitope, Binding of IgA to the hinge region of IgG1 covers part of the physiologically active Pc domain, immobilizes the Fab arms, and thereby can be expected to exert immunoregulatory functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:00:51