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Titolo:
IL-12 ENHANCES VACCINE-INDUCED IMMUNITY TO SCHISTOSOMES BY AUGMENTINGBOTH HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES AGAINST THE PARASITE
Autore:
WYNN TA; REYNOLDS A; JAMES S; CHEEVER AW; CASPAR P; HIENY S; JANKOVIC D; STRAND M; SHER A;
Indirizzi:
NIAID,PARASIT DIS LAB,IMMUNOBIOL SECT,NIH,BLDG 4,ROOM 126,9000 ROCKVILLE PIKE BETHESDA MD 20892 JOHNS HOPKINS UNIV,DEPT PHARMACOL & MOL SCI BALTIMORE MD 21205
Titolo Testata:
The Journal of immunology
fascicolo: 9, volume: 157, anno: 1996,
pagine: 4068 - 4078
SICI:
0022-1767(1996)157:9<4068:IEVITS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-ATTENUATED CERCARIAE; CD4+ T-CELLS; INTERFERON-GAMMA PRODUCTION; CYTOKINE GENE-EXPRESSION; PROTECTIVE IMMUNITY; IFN-GAMMA; IRRADIATED CERCARIAE; LEISHMANIA-MAJOR; LISTERIA-MONOCYTOGENES; MANSONI SCHISTOSOMULA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Wynn et al., "IL-12 ENHANCES VACCINE-INDUCED IMMUNITY TO SCHISTOSOMES BY AUGMENTINGBOTH HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES AGAINST THE PARASITE", The Journal of immunology, 157(9), 1996, pp. 4068-4078

Abstract

The production of Th1-type cytokines is associated with:strong cell-mediated immunity, while Th2-type cytokines typically dominate humoral immune responses. In mice vaccinated a single time with attenuated cercariae of Schistosoma mansoni, the protection induced is associated with Th1 cytokine-dependent, cell-mediated immunity. In contrast, mice vaccinated multiple times display a more Th2-type dominant cytokine response and develop Ab-dependent resistance. We have previously shown that IL-12 enhances cell-mediated immunity in singly vaccinated mice, Inthe present study, we asked what effects administering IL-12 as an adjuvant would have on the development of a protective humoral response in multiply immunized animals. We found that multiply immunized/lL-12-treated mice displayed a marked increase in resistance to challenge infection, with some animals demonstrating complete protection. The IL-12-vaccinated mice developed strongly polarized Th1 responses but, importantly, also showed significant increases In parasite-specific Ab and, in particular, IgG2a, IgG26, and IgG1 isotypes. Passive transfer demonstrated an enhanced ability of serum from these animals to protect naive recipients. In addition, animals vaccinated in the presence of IL-12 also developed macrophages with increased nitric oxide-dependent killing activity against the parasites. Together, these data demonstrate that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:58:29