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Titolo:
IN THE ABSENCE OF ENDOGENOUS IFN-GAMMA, MICE DEVELOP UNIMPAIRED IL-12RESPONSES TO TOXOPLASMA-GONDII WHILE FAILING TO CONTROL ACUTE INFECTION
Autore:
SCHARTONKERSTEN TM; WYNN TA; DENKERS EY; BALA S; GRUNVALD E; HIENY S; GAZZINELLI RT; SHER A;
Indirizzi:
NIAID,PARASIT DIS LAB,IMMUNOBIOL SECT,NIH,BLDG 4,ROOM 132 BETHESDA MD20892 US FDA,DIV ANTIVIRAL DRUG PROD ROCKVILLE MD 20857 UNIV FED MINAS GERAIS,DEPT BIOCHEM & IMMUNOL BELO HORIZONT MG BRAZIL
Titolo Testata:
The Journal of immunology
fascicolo: 9, volume: 157, anno: 1996,
pagine: 4045 - 4054
SICI:
0022-1767(1996)157:9<4045:ITAOEI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA; LEISHMANIA-MAJOR; INTERLEUKIN-12 PRODUCTION; LISTERIA-MONOCYTOGENES; NITRIC-OXIDE; IN-VIVO; RESISTANCE; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Schartonkersten et al., "IN THE ABSENCE OF ENDOGENOUS IFN-GAMMA, MICE DEVELOP UNIMPAIRED IL-12RESPONSES TO TOXOPLASMA-GONDII WHILE FAILING TO CONTROL ACUTE INFECTION", The Journal of immunology, 157(9), 1996, pp. 4045-4054

Abstract

The relationship between IFN-gamma and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in T. gondii-exposed lFN-gamma knockout (gko) mice. Gko mice,in contrast to wild-type (wt) animals, rapidly succumbed to infectionwith either the avirulent ME49 strain or, surprisingly, an attenuatedtemperature-sensitive mutant strain, ts4. Microscopic examination of peritoneal exudates from infected gko mice demonstrated that mortalityis associated with unchecked tachyzoite replication. Nevertheless, both wt and gko animals developed a peritoneal inflammatory response that in gko animals was greater due to a 5- to 10-fold increase in the number of granulocytes recruited to the site of infection. In addition, IL-12 production in gko mice was both unimpaired and functional since a significant, albeit lower than wt, IL-12-dependent NK cell response developed in these animals. Regardless, no evidence for an IFN-gamma-independent protective function for IL-12 or NK cells was apparent since in vivo treatment of gko mice with an IL-12-neutralizing mAb ablatedthe NK cell response, but did not decrease survival. Together, these data identify distinct functions for IL-12 and IFN-gamma in host resistance to T. gondii: IL-12 precedes and initiates synthesis of IFN-gamma, while the latter lymphokine directly controls parasite growth and diminishes the contribution of IL-4- and IL-5-producing T cell subsets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:23:34