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Titolo:
CONSTRUCTING A NEW NIGROSTRIATAL PATHWAY IN THE PARKINSONIAN MODEL WITH BRIDGED NEURAL TRANSPLANTATION IN SUBSTANTIA-NIGRA
Autore:
ZHOU FC; CHIANG YH; WANG Y;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT ANAT,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,PROGRAM MED NEUROBIOL INDIANAPOLIS IN 46202 NATL DEF MED CTR,DEPT PHARMACOL TAIPEI TAIWAN
Titolo Testata:
The Journal of neuroscience
fascicolo: 21, volume: 16, anno: 1996,
pagine: 6965 - 6974
SICI:
0270-6474(1996)16:21<6965:CANNPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT BRAIN; GLUTAMATE RECEPTORS; STRIATAL GRAFTS; DOPAMINE; LESION; RECOVERY; SURVIVAL; DISEASE; NEURONS; ELECTROCHEMISTRY;
Keywords:
EXCITATORY AMINO ACID; NEURAL TRANSPLANT; DOPAMINE; PATHWAY REPAIR; VOLTAMMETRY; HRP/IMMUNOCYTOCHEMISTRY DOUBLE STAINING; ROTATIONAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
F.C. Zhou et al., "CONSTRUCTING A NEW NIGROSTRIATAL PATHWAY IN THE PARKINSONIAN MODEL WITH BRIDGED NEURAL TRANSPLANTATION IN SUBSTANTIA-NIGRA", The Journal of neuroscience, 16(21), 1996, pp. 6965-6974

Abstract

The physical repair and restoration of a completely damaged pathway in the brain has not been achieved previously, In a previous study, using excitatory amino acid bridging and fetal neural transplantation, wedemonstrated that a bridged mesencephalic transplant in the substantia nigra generated an artificial nerve pathway that reinnervated the striatum of 6-hydroxydopamine (6-OHDA)-lesioned rats. In the current study, we report that a bridged mesencephalic transplant can anatomically, neurochemically, and functionally reinstate the 6-OHDA-eradicated nigro-striatal pathway. An excitatory amino acid, kainic acid, laid downin a track during the transplant generated a trophic environment thateffectively guided the robust growth of transplanted neuronal fibers in a bundle to innervate the distal striatum, Growth occurred at the remarkable speed of similar to 200 mu m/d. Two separate and distinct types of dopamine (DA) innervation from the transplant have been achieved for the first time: (1) DA innervation of the striatum, and (2) DA innervation of the pars reticularis of the substantia nigra. In addition, neuronal tracing revealed that reciprocal connections were achieved. The grafted DA neurons in the SNr innervated the host's striatum, whereas the host's striatal neurons, in turn, innervated the graft within 3-8 weeks. Electrochemical volt- ammetry recording revealed the restoration of DA release and clearance in a broad striatal area associated with the DA reinnervation. Furthermore, the amphetamine-induced rotation was attenuated, which indicates that the artificial pathways weremotor functional. This study provides additional evidences that our bridged transplantation technique is a potential means for the repair of a completely damaged neuronal pathway.

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Documento generato il 09/07/20 alle ore 17:34:05