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Titolo:
A SNARE COMPLEX CONTAINING SYNTAXIN-3 IS PRESENT IN RIBBON SYNAPSES OF THE RETINA
Autore:
MORGANS CW; BRANDSTATTER JH; KELLERMAN J; BETZ H; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,NEUROANAT ABT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH,DEPT NEUROCHEM D-60528 FRANKFURT GERMANY MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 21, volume: 16, anno: 1996,
pagine: 6713 - 6721
SICI:
0270-6474(1996)16:21<6713:ASCCSI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC VESICLE DOCKING; CALCIUM CHANNELS; N-TYPE; NEUROTRANSMITTER RELEASE; VERTEBRATE RETINA; BIPOLAR CELLS; HAIR-CELLS; PROTEIN; FUSION; TERMINALS;
Keywords:
RETINA; RIBBON SYNAPSE; SYNAPTIC VESICLE EXOCYTOSIS; SNARE COMPLEX; SYNLAXIN 3; SNAP-25; COMPLEXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Morgans et al., "A SNARE COMPLEX CONTAINING SYNTAXIN-3 IS PRESENT IN RIBBON SYNAPSES OF THE RETINA", The Journal of neuroscience, 16(21), 1996, pp. 6713-6721

Abstract

In contrast to conventional synapses, which release neurotransmitter transiently, ribbon synapses formed by photoreceptors and bipolar cells of the retina release neurotransmitter continuously and modulate therate in response to light. Both modes of release are mediated by synaptic vesicles but probably differ in the regulation of docking and fusion of synaptic vesicles with the plasma membrane. We have found that syntaxin 1, an essential component of the core fusion complex in conventional synapses, is absent from ribbon synapses of the retina, raising the possibility that these synapses contain a different type of syntaxin or syntaxin-like protein. By immuno-precipitating syntaxin 1-depleted retina and brain extracts with a SNAP-25 antibody and microsequencing the precipitated proteins, syntaxin 3 was detected in retina complexed with SNAP-25, synaptobrevin, and complexin. Using an antisyntaxin 3 antiserum, syntaxin 3 was demonstrated to be present at high levels in retina compared to brain. Immunofluorescent staining of rat retina sections confirmed that syntaxin 3 is expressed by photoreceptor andbipolar cells in the retina. Thus, in the retina, expression of syntaxin 3 is correlated with ribbon synapses and may play a role in the tonic release of neurotransmitter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:46:08