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Titolo:
NEUROLOGICAL AND DEVELOPMENTAL PROBLEMS IN PEDIATRIC HIV-INFECTION
Autore:
MINTZ M;
Indirizzi:
COOPER HOSP UNIV MED CTR CAMDEN NJ 08103
Titolo Testata:
The Journal of nutrition
fascicolo: 10, volume: 126, anno: 1996, supplemento:, S
pagine: 2663 - 2673
SICI:
0022-3166(1996)126:10<2663:NADPIP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY-SYNDROME; TERM ZIDOVUDINE THERAPY; CENTRAL-NERVOUS-SYSTEM; AIDS DEMENTIA COMPLEX; CEREBROSPINAL-FLUID; TYPE-1 INFECTION; THIAMINE-DEFICIENCY; CHILDREN; ENCEPHALOPATHY;
Keywords:
HIV INFECTION; NEUROLOGICAL FUNCTION; PROGRESSIVE ENCEPHALOPATHY; NUTRITION; NEUROPATHOGENESIS; OPPORTUNISTIC INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
M. Mintz, "NEUROLOGICAL AND DEVELOPMENTAL PROBLEMS IN PEDIATRIC HIV-INFECTION", The Journal of nutrition, 126(10), 1996, pp. 2663-2673

Abstract

Human immunodeficiency virus type-1 (HIV-1)-associated neurologic disease, known as ''HIV-1-associated progressive encephalopathy'' (PE), is a common concomitant in the progression towards AIDS. PE, characterized by a triad of symptoms including impaired brain growth, progressive motor dysfunction, and loss or plateau of developmental milestones, is believed to result from both direct and indirect effects of HIV-I infection on the central nervous system (CNS). Consequent to the hallmark systemic immune deficiency of HIV infection, the CNS becomes susceptible to opportunistic infections which add further morbidity and mortality, and may contribute either directly or indirectly to neurologic symptoms which can often mimic PE. Static encephalopathies (SE) represent fixed, nonprogressive neurologic or neurodevelopmental deficits inHIV-infected children. SE may or may not be caused by HIV infection but are often associated with such identifiable insults as prematurity,in utero exposure to toxins or infectious agents, or head trauma. Additional neurological manifestations of HIV infection are seizures, cerebrovascular complications (i.e., stroke), myelopathies, neuromuscularsyndromes, and CNS complications of opportunistic infections. Neurobehavioral aberrations have also been observed in pediatric HIV infection. In addition to the neuropathogenesis, theories regarding the timingand detection of the neurological problems associated with pediatric HIV infection are discussed along with a presentation of current treatment paradigms and their rationales. The importance of identifying thenumerous environmental factors, including nutritional status, that may confound the ability to discriminate between a primary or secondary role of HIV infection in the various neurological problems of HIV infection is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:46:54